PPARD |
---|
|
Наявні структури |
---|
PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1GWX, 1Y0S, 2AWH, 2B50, 2BAW, 2ENV, 2GWX, 2J14, 2Q5G, 2XYJ, 2XYW, 2XYX, 2ZNP, 2ZNQ, 3D5F, 3DY6, 3ET2, 3GWX, 3GZ9, 3OZ0, 3PEQ, 3SP9, 3TKM | | |
Ідентифікатори |
---|
Символи | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB, peroxisome proliferator activated receptor delta |
---|
Зовнішні ІД | OMIM: 600409 MGI: 101884 HomoloGene: 4544 GeneCards: PPARD |
---|
|
Пов'язані генетичні захворювання |
---|
цукровий діабет 2-го типу, diabetic cataract[1] |
|
Реагує на сполуку |
---|
GW0742X, GW-501516, третиноїн, elafibranor, sodelglitazar, indeglitazar[2] |
Онтологія гена |
---|
Молекулярна функція | • sequence-specific DNA binding • GO:0001105 transcription coactivator activity • zinc ion binding • зв'язування з іоном металу • steroid hormone receptor activity • fatty acid binding • GO:0001948, GO:0016582 protein binding • linoleic acid binding • protein heterodimerization activity • lipid binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • NF-kappaB binding • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • nuclear receptor coactivator activity • signaling receptor activity |
---|
Клітинна компонента | • нуклеоплазма • клітинне ядро • RNA polymerase II transcription regulator complex |
---|
Біологічний процес | • fatty acid catabolic process • positive regulation of myoblast proliferation • positive regulation of epidermis development • диференціація клітин • negative regulation of smooth muscle cell proliferation • negative regulation of myoblast differentiation • GO:0009373 regulation of transcription, DNA-templated • placenta development • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of smooth muscle cell migration • Загоєння ран • mRNA transcription • cholesterol metabolic process • negative regulation of apoptotic process • response to glucose • response to activity • response to organic substance • generation of precursor metabolites and energy • regulation of fat cell differentiation • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • response to vitamin A • heart development • cell-substrate adhesion • keratinocyte proliferation • GO:1901313 positive regulation of gene expression • proteoglycan metabolic process • regulation of cell population proliferation • negative regulation of cell growth • fatty acid oxidation • positive regulation of cell population proliferation • glucose metabolic process • phospholipid biosynthetic process • negative regulation of epithelial cell proliferation • positive regulation of skeletal muscle tissue regeneration • apoptotic signaling pathway • vitamin A metabolic process • positive regulation of phosphatidylinositol 3-kinase signaling • keratinocyte migration • adipose tissue development • transcription initiation from RNA polymerase II promoter • regulation of skeletal muscle satellite cell proliferation • positive regulation of fat cell differentiation • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of inflammatory response • cellular response to lipopolysaccharide • cellular response to hypoxia • negative regulation of collagen biosynthetic process • positive regulation of insulin secretion • steroid hormone mediated signaling pathway • GO:0097285 апоптоз • проліферація • GO:1901227 negative regulation of transcription by RNA polymerase II • intracellular receptor signaling pathway • axon ensheathment • decidualization • fatty acid transport • embryo implantation • negative regulation of pri-miRNA transcription by RNA polymerase II • lipid metabolism • fatty acid beta-oxidation • glucose transmembrane transport • fatty acid metabolic process • multicellular organism development • hormone-mediated signaling pathway • negative regulation of cholesterol storage • regulation of lipid metabolic process • response to lipid • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II |
---|
Джерела:Amigo / QuickGO | |
Шаблон експресії |
---|
|
Більше даних |
Ортологи |
---|
Види | Людина | Миша |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (мРНК) | | NM_001171818 NM_001171819 NM_001171820 NM_006238 NM_177435 |
| |
---|
RefSeq (білок) | | NP_001165289 NP_001165290 NP_001165291 NP_006229 NP_803184 |
| |
---|
Локус (UCSC) | Хр. 6: 35.34 – 35.43 Mb | Хр. 17: 28.23 – 28.3 Mb |
---|
PubMed search | [3] | [4] |
---|
Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
|