PITX2 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 2L7F, 2L7M, 2LKX | | |
Ідентифікатори |
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Символи | PITX2, ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS, paired like homeodomain 2, ASGD4 |
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Зовнішні ІД | OMIM: 601542 MGI: 109340 HomoloGene: 55454 GeneCards: PITX2 |
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Пов'язані генетичні захворювання |
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Axenfeld-Rieger syndrome type 1, iridogoniodysgenesis syndrome, ring dermoid of cornea, Rieger anomaly[1] |
Онтологія гена |
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Молекулярна функція | • identical protein binding • protein homodimerization activity • GO:0000975 transcription cis-regulatory region binding • sequence-specific DNA binding • DNA binding • GO:0001105 transcription coactivator activity • chromatin DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • chromatin binding • ribonucleoprotein complex binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • transcription factor binding • phosphoprotein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific |
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Клітинна компонента | • клітинне ядро • цитоплазма • transcription regulator complex • нуклеоплазма |
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Біологічний процес | • response to vitamin A • female gonad development • vascular associated smooth muscle cell differentiation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • skeletal muscle tissue development • cell proliferation involved in outflow tract morphogenesis • prolactin secreting cell differentiation • in utero embryonic development • pituitary gland development • васкулогенез • regulation of cell population proliferation • myoblast fusion • hair cell differentiation • spleen development • GO:0009373 regulation of transcription, DNA-templated • transcription by RNA polymerase II • embryonic camera-type eye development • ventricular septum morphogenesis • endodermal digestive tract morphogenesis • determination of left/right symmetry • cardiac muscle tissue development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • subthalamic nucleus development • ventricular cardiac muscle cell development • left/right axis specification • hypothalamus cell migration • animal organ morphogenesis • regulation of cell migration • heart development • embryonic digestive tract morphogenesis • branching involved in blood vessel morphogenesis • cardiac muscle cell differentiation • digestive system development • multicellular organism development • atrioventricular valve development • pulmonary vein morphogenesis • cardiac neural crest cell migration involved in outflow tract morphogenesis • embryonic hindlimb morphogenesis • lung development • superior vena cava morphogenesis • positive regulation of DNA binding • extraocular skeletal muscle development • pulmonary myocardium development • deltoid tuberosity development • atrial cardiac muscle tissue morphogenesis • male gonad development • anatomical structure morphogenesis • brain development • neuron differentiation • odontogenesis of dentin-containing tooth • Wnt signaling pathway • left lung morphogenesis • somatotropin secreting cell differentiation • positive regulation of myoblast proliferation • camera-type eye development • response to hormone • odontogenesis • iris morphogenesis • neuron migration • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_000325 NM_001204397 NM_001204398 NM_001204399 NM_153426
| NM_153427 |
| | NM_001042502 NM_001042504 NM_001286942 NM_001287048 NM_011098 |
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RefSeq (білок) | NP_000316 NP_001191326 NP_001191327 NP_001191328 NP_700475
| NP_700476 |
| | NP_001035967 NP_001035969 NP_001273871 NP_001273977 NP_035228 |
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Локус (UCSC) | Хр. 4: 110.62 – 110.64 Mb | Хр. 3: 128.99 – 129.01 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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