NR1H2 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1P8D, 1PQ6, 1PQ9, 1PQC, 1UPV, 1UPW, 3KFC, 3L0E, 4DK7, 4DK8, 4RAK, 5HJP, 4NQA, 5I4V,%%s4NQA | | |
Ідентифікатори |
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Символи | NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR, Liver X receptor beta, nuclear receptor subfamily 1 group H member 2 |
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Зовнішні ІД | OMIM: 600380 MGI: 1352463 HomoloGene: 21397 GeneCards: NR1H2 |
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Реагує на сполуку |
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(25R)-cholest-5-ene-3β,26-diol, desmosterol[1] |
Онтологія гена |
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Молекулярна функція | • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • ATPase binding • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • зв'язування з іоном металу • retinoid X receptor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • steroid hormone receptor activity • apolipoprotein A-I receptor binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity |
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Клітинна компонента | • цитоплазма • нуклеоплазма • клітинне ядро • RNA polymerase II transcription regulator complex |
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Біологічний процес | • positive regulation of high-density lipoprotein particle assembly • negative regulation of proteolysis • positive regulation of triglyceride biosynthetic process • GO:0051247, GO:0051200 positive regulation of protein metabolic process • negative regulation of interferon-gamma-mediated signaling pathway • positive regulation of cholesterol transport • GO:0009373 regulation of transcription, DNA-templated • cellular lipid metabolic process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of secretion of lysosomal enzymes • positive regulation of lipid storage • positive regulation of lipoprotein lipase activity • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of fatty acid biosynthetic process • negative regulation of gene expression • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of cholesterol storage • negative regulation of pinocytosis • GO:1901313 positive regulation of gene expression • retinoic acid receptor signaling pathway • positive regulation of cholesterol efflux • positive regulation of pancreatic juice secretion • lipid homeostasis • negative regulation of lipid transport • transcription initiation from RNA polymerase II promoter • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of macrophage derived foam cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • steroid hormone mediated signaling pathway • cholesterol homeostasis • lipid metabolism • multicellular organism development • диференціація клітин • cellular response to lipopolysaccharide • negative regulation of cold-induced thermogenesis • intracellular receptor signaling pathway |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | | NM_001285517 NM_001285518 NM_001285519 NM_009473 |
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RefSeq (білок) | | NP_001243576 NP_009052 NP_009052.3 |
| | NP_001272446 NP_001272447 NP_001272448 NP_033499 |
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Локус (UCSC) | Хр. 19: 50.33 – 50.38 Mb | Хр. 7: 44.2 – 44.2 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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