NFATC2 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1A02, 1OWR, 1P7H, 1PZU, 2AS5, 2O93, 3QRF | | |
Ідентифікатори |
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Символи | NFATC2, NFAT1, NFATP, nuclear factor of activated T-cells 2, nuclear factor of activated T cells 2 |
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Зовнішні ІД | OMIM: 600490 MGI: 102463 HomoloGene: 7861 GeneCards: NFATC2 |
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Пов'язані генетичні захворювання |
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бічний аміотрофічний склероз[1] |
Онтологія гена |
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Молекулярна функція | • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • chromatin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • GO:0000975 transcription cis-regulatory region binding • phosphatase binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific |
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Клітинна компонента | • цитоплазма • transcription regulator complex • нуклеоплазма • клітинне ядро • гіалоплазма • Рибонуклеопротеїни |
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Біологічний процес | • B cell receptor signaling pathway • GO:0009373 regulation of transcription, DNA-templated • GO:0032617 cytokine production • calcineurin-NFAT signaling cascade • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • myotube cell development • transcription, DNA-templated • cellular response to DNA damage stimulus • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • Fc-epsilon receptor signaling pathway • positive regulation of myoblast fusion • GO:1901313 positive regulation of gene expression • positive regulation of B cell proliferation • cell migration • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of regulatory T cell differentiation • negative regulation of vascular associated smooth muscle cell differentiation |
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Джерела:Amigo / QuickGO | |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_001136021 NM_001258292 NM_001258294 NM_001258295 NM_001258296
| NM_001258297 NM_012340 NM_173091 |
| NM_001037177 NM_001037178 NM_001136073 NM_001291168 NM_001291169
| NM_001291170 NM_001291171 NM_001291172 NM_001291173 NM_001291174 NM_001291175 NM_001291176 NM_001291177 NM_001291178 NM_001291179 NM_010899 |
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RefSeq (білок) | NP_001129493 NP_001245221 NP_001245223 NP_001245224 NP_001245225
| NP_001245226 NP_036472 NP_775114 |
| NP_001032254 NP_001032255 NP_001129545 NP_001278097 NP_001278098
| NP_001278099 NP_001278100 NP_001278101 NP_001278102 NP_001278103 NP_001278104 NP_001278105 NP_001278106 NP_001278107 NP_001278108 NP_035029 |
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Локус (UCSC) | Хр. 20: 51.39 – 51.56 Mb | Хр. 2: 168.32 – 168.44 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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