IRF3 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 3QU6, 1J2F, 1QWT, 1T2K, 1ZOQ, 2O61, 2O6G, 2PI0, 3A77, 5JEO, 5JEK, 5JER, 5JEM, 5JEL, 5JEJ | | |
Ідентифікатори |
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Символи | IRF3, entrez:3661, IIAE7, interferon regulatory factor 3 |
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Зовнішні ІД | OMIM: 603734 MGI: 1859179 HomoloGene: 1208 GeneCards: IRF3 |
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Онтологія гена |
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Молекулярна функція | • DNA binding • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001104 transcription coregulator activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • protein domain specific binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • sequence-specific DNA binding • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific |
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Клітинна компонента | • цитоплазма • нуклеоплазма • клітинне ядро • гіалоплазма |
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Біологічний процес | • GO:0097285 апоптоз • positive regulation of type I interferon-mediated signaling pathway • macrophage apoptotic process • GO:0009373 regulation of transcription, DNA-templated • response to bacterium • response to exogenous dsRNA • positive regulation of interferon-alpha production • MDA-5 signaling pathway • interferon-gamma-mediated signaling pathway • процес імунної системи • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • cellular response to dsRNA • transcription, DNA-templated • cellular response to DNA damage stimulus • TRIF-dependent toll-like receptor signaling pathway • response to lipopolysaccharide • defense response to virus • type I interferon signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of type I interferon production • programmed necrotic cell death • GO:0022415 viral process • cellular response to lipopolysaccharide • positive regulation of type I interferon production • lipopolysaccharide-mediated signaling pathway • positive regulation of interferon-beta production • вроджений імунітет • regulation of type I interferon production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of defense response to virus by host • регуляція експресії генів • regulation of inflammatory response • cellular response to exogenous dsRNA • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_001197122 NM_001197123 NM_001197124 NM_001197125 NM_001197126
| NM_001197127 NM_001197128 NM_001571 |
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RefSeq (білок) | NP_001184051 NP_001184052 NP_001184053 NP_001184054 NP_001184055
| NP_001184056 NP_001184057 NP_001562 NP_001184053.1 NP_001184056.1 NP_001184057.1 |
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Локус (UCSC) | Хр. 19: 49.66 – 49.67 Mb | Хр. 7: 44.65 – 44.65 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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