PPARA |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR, 4CI4, 5AZT | | |
Ідентифікатори |
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Символи | PPARA, NR1C1, PPAR, PPARalpha, hPPAR, peroxisome proliferator activated receptor alpha, PPAR-alpha |
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Зовнішні ІД | MGI: 104740 HomoloGene: 21047 GeneCards: PPARA |
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Реагує на сполуку |
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bezafibrate, ciprofibrate, clofibrate, farglitazar, fenofibrate, gemfibrozil, oleic monoethanolamide, pirinixic acid[1] |
Онтологія гена |
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Молекулярна функція | • DNA binding • sequence-specific DNA binding • protein domain specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • зв'язування з іоном металу • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • steroid hormone receptor activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001948, GO:0016582 protein binding • ubiquitin conjugating enzyme binding • lipid binding • transcription factor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • signaling receptor activity • GO:0032403 protein-containing complex binding • transcription coactivator binding • phosphatase binding • NFAT protein binding • MDM2/MDM4 family protein binding • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • fatty acid binding • nuclear receptor coactivator activity |
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Клітинна компонента | • клітинне ядро • нуклеоплазма • RNA polymerase II transcription regulator complex |
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Біологічний процес | • lipoprotein metabolic process • negative regulation of pri-miRNA transcription by RNA polymerase II • positive regulation of fatty acid beta-oxidation • negative regulation of glycolytic process • response to hypoxia • GO:0009373 regulation of transcription, DNA-templated • negative regulation of blood pressure • lipid metabolism • ритмічний процес • Загоєння ран • negative regulation of leukocyte cell-cell adhesion • GO:1901227 negative regulation of transcription by RNA polymerase II • fatty acid transport • negative regulation of protein binding • negative regulation of appetite • circadian regulation of gene expression • transcription, DNA-templated • fatty acid metabolic process • behavioral response to nicotine • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of cholesterol storage • response to insulin • heart development • intracellular receptor signaling pathway • negative regulation of transcription regulatory region DNA binding • negative regulation of sequestering of triglyceride • regulation of circadian rhythm • regulation of fatty acid metabolic process • epidermis development • регуляція експресії генів • enamel mineralization • positive regulation of gluconeogenesis • transcription initiation from RNA polymerase II promoter • negative regulation of inflammatory response • negative regulation of macrophage derived foam cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • steroid hormone mediated signaling pathway • negative regulation of neuron death • positive regulation of fatty acid oxidation • regulation of lipid metabolic process • GO:0072468 сигнальна трансдукція • multicellular organism development • hormone-mediated signaling pathway • диференціація клітин • response to lipid • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of cell growth involved in cardiac muscle cell development |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_001001928 NM_001001929 NM_001001930 NM_005036 NM_032644
| NM_001362872 NM_001362873 NM_001393941 NM_001393942 NM_001393943 NM_001393944 NM_001393945 NM_001393946 NM_001393947 |
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RefSeq (білок) | | NP_001001928 NP_005027 NP_001349801 NP_001349802 |
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Локус (UCSC) | Хр. 22: 46.15 – 46.24 Mb | Хр. 15: 85.62 – 85.69 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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