NFKB1 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1MDI, 1MDJ, 1MDK, 1NFI, 1SVC, 2DBF, 2O61, 3GUT | | |
Ідентифікатори |
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Символи | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50, CVID12, nuclear factor kappa B subunit 1, NF-kappa-B1, NF-kB, NF-kappabeta |
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Зовнішні ІД | OMIM: 164011 MGI: 97312 HomoloGene: 2971 GeneCards: NFKB1 |
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Пов'язані генетичні захворювання |
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шизофренія, immunodeficiency, common variable, 12[1] |
Онтологія гена |
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Молекулярна функція | • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • RNA polymerase II transcription regulatory region sequence-specific DNA binding • transcription factor binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • protein homodimerization activity • chromatin binding • GO:0001948, GO:0016582 protein binding • DNA binding • sequence-specific DNA binding • actinin binding • identical protein binding • GO:0000975 transcription cis-regulatory region binding • protein heterodimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific |
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Клітинна компонента | • цитоплазма • мітохондрія • клітинне ядро • I-kappaB/NF-kappaB complex • нуклеоплазма • extracellular region • гіалоплазма • secretory granule lumen • specific granule lumen |
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Біологічний процес | • cellular response to interleukin-6 • positive regulation of canonical Wnt signaling pathway • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • negative regulation of vitamin D biosynthetic process • Fc-epsilon receptor signaling pathway • cellular response to mechanical stimulus • NIK/NF-kappaB signaling • stress-activated MAPK cascade • negative regulation of inflammatory response • GO:0097285 апоптоз • response to muscle stretch • GO:0009373 regulation of transcription, DNA-templated • stimulatory C-type lectin receptor signaling pathway • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of calcidiol 1-monooxygenase activity • positive regulation of hyaluronan biosynthetic process • membrane protein intracellular domain proteolysis • inflammatory response • I-kappaB kinase/NF-kappaB signaling • positive regulation of miRNA metabolic process • cellular response to nicotine • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of macrophage derived foam cell differentiation • positive regulation of NF-kappaB transcription factor activity • negative regulation of cholesterol transport • GO:0045996 negative regulation of transcription, DNA-templated • GO:0032697 negative regulation of cytokine production • positive regulation of lipid storage • cellular response to dsRNA • T cell receptor signaling pathway • positive regulation of type I interferon production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 сигнальна трансдукція • cellular response to lipopolysaccharide • cellular response to interleukin-1 • вроджений імунітет • negative regulation of apoptotic process • negative regulation of gene expression • neutrophil degranulation • cellular response to tumor necrosis factor • cellular response to angiotensin • interleukin-1-mediated signaling pathway |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_001165412 NM_003998 NM_001319226 NM_001382625 NM_001382626
| NM_001382627 NM_001382628 |
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RefSeq (білок) | NP_001158884 NP_001306155 NP_003989 NP_001369554 NP_001369555
| NP_001369556 NP_001369557 NP_001158884.1 NP_001306155.1 |
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Локус (UCSC) | Хр. 4: 102.5 – 102.62 Mb | Хр. 3: 135.29 – 135.4 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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