GLI3 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | | |
Ідентифікатори |
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Символи | GLI3, ACLS, GCPS, GLI3-190, GLI3FL, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV, GLI family zinc finger 3 |
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Зовнішні ІД | OMIM: 165240 MGI: 95729 HomoloGene: 139 GeneCards: GLI3 |
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Пов'язані генетичні захворювання |
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макулодистрофія, поліноз, Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome[1] |
Онтологія гена |
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Молекулярна функція | • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • histone deacetylase binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • зв'язування з іоном металу • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • beta-catenin binding • chromatin binding • GO:0001948, GO:0016582 protein binding • histone acetyltransferase binding • nucleic acid binding • DNA binding • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • mediator complex binding |
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Клітинна компонента | • цитоплазма • гіалоплазма • transcription repressor complex • клітинне ядро • nuclear speck • cell projection • mediator complex • війка • GO:0035085 Аксонема • нуклеоплазма • ciliary base • ciliary tip |
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Біологічний процес | • embryonic skeletal system morphogenesis • pattern specification process • lateral semicircular canal development • negative regulation of neuron differentiation • T cell differentiation in thymus • tongue development • nose morphogenesis • optic nerve morphogenesis • smoothened signaling pathway involved in ventral spinal cord interneuron specification • anatomical structure formation involved in morphogenesis • oligodendrocyte differentiation • hindgut morphogenesis • spinal cord dorsal/ventral patterning • thymocyte apoptotic process • mammary gland development • limb development • odontogenesis of dentin-containing tooth • positive regulation of chondrocyte differentiation • embryonic digestive tract morphogenesis • inner ear development • metanephros development • melanocyte differentiation • negative regulation of canonical Wnt signaling pathway • negative regulation of cell population proliferation • regulation of apoptotic process • positive regulation of neuroblast proliferation • GO:0009373 regulation of transcription, DNA-templated • limb morphogenesis • negative regulation of smoothened signaling pathway • розвиток нирки • lung development • tube development • embryonic organ development • lateral ganglionic eminence cell proliferation • negative regulation of cell differentiation • embryonic digit morphogenesis • negative regulation of alpha-beta T cell differentiation • in utero embryonic development • transcription, DNA-templated • negative thymic T cell selection • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • central nervous system development • telencephalon development • branching involved in ureteric bud morphogenesis • embryonic limb morphogenesis • neural tube development • positive regulation of protein import into nucleus • smoothened signaling pathway • camera-type eye development • spinal cord motor neuron differentiation • positive regulation of alpha-beta T cell differentiation • lambdoid suture morphogenesis • regulation of bone development • roof of mouth development • proximal/distal pattern formation • GO:1903374 anatomical structure development • Загоєння ран • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • response to estrogen • cerebral cortex radial glia-guided migration • positive regulation of osteoblast differentiation • developmental growth • pallium development • mammary gland specification • frontal suture morphogenesis • anterior semicircular canal development • регуляція експресії генів • GO:0045996 negative regulation of transcription, DNA-templated • dorsal/ventral pattern formation • branching morphogenesis of an epithelial tube • embryonic digestive tract development • subpallium development • sagittal suture morphogenesis • forebrain dorsal/ventral pattern formation • protein processing • axon guidance • brain development • smoothened signaling pathway involved in dorsal/ventral neural tube patterning • forebrain radial glial cell differentiation • regulation of cell population proliferation • smoothened signaling pathway involved in spinal cord motor neuron cell fate specification • layer formation in cerebral cortex • embryonic morphogenesis • artery development • cell differentiation involved in kidney development • регуляція диференціювання клітин • forebrain development • neuron fate commitment • hippocampus development • camera-type eye morphogenesis • anterior/posterior pattern specification • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • prostate gland development • liver regeneration |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 7: 41.96 – 42.26 Mb | Хр. 13: 15.64 – 15.9 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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