HIF1A |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J | | |
Ідентифікатори |
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Символи | HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, HIF-1α |
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Зовнішні ІД | OMIM: 603348 MGI: 106918 HomoloGene: 1171 GeneCards: HIF1A |
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Онтологія гена |
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Молекулярна функція | • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • histone deacetylase binding • transcription factor binding • enzyme binding • GO:0001948, GO:0016582 protein binding • histone acetyltransferase binding • protein kinase binding • Hsp90 protein binding • sequence-specific DNA binding • DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • ubiquitin protein ligase binding • protein heterodimerization activity • E-box binding • p53 binding • protein domain specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II transcription regulatory region sequence-specific DNA binding |
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Клітинна компонента | • цитоплазма • гіалоплазма • клітинне ядро • nuclear speck • motile cilium • transcription regulator complex • RNA polymerase II transcription regulator complex • axon cytoplasm • нуклеоплазма • ядерні тільця • GO:0009327 protein-containing complex |
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Біологічний процес | • GO:1904089 negative regulation of neuron apoptotic process • B-1 B cell homeostasis • regulation of transforming growth factor beta2 production • muscle cell cellular homeostasis • outflow tract morphogenesis • negative regulation of ossification • heart looping • negative regulation of TOR signaling • blood vessel development • hemoglobin biosynthetic process • Ангіогенез • positive regulation of chemokine-mediated signaling pathway • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of hormone biosynthetic process • negative regulation of mesenchymal cell apoptotic process • regulation of aerobic respiration • positive regulation of neuroblast proliferation • dopaminergic neuron differentiation • lactate metabolic process • GO:0009373 regulation of transcription, DNA-templated • blood vessel morphogenesis • positive regulation of erythrocyte differentiation • glucose homeostasis • vascular endothelial growth factor production • regulation of thymocyte apoptotic process • positive regulation of epithelial cell migration • negative regulation of thymocyte apoptotic process • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • axonal transport of mitochondrion • positive regulation of macroautophagy • cartilage development • positive regulation of nitric-oxide synthase activity • regulation of transcription from RNA polymerase II promoter in response to hypoxia • лактація • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • positive regulation of pri-miRNA transcription by RNA polymerase II • digestive tract morphogenesis • диференціація клітин • neural fold elevation formation • positive regulation of autophagy • retina vasculature development in camera-type eye • collagen metabolic process • embryonic placenta development • negative regulation of apoptotic process • positive regulation of angiogenesis • regulation of glycolytic process • Епітеліально-мезенхімальний перехід • cerebral cortex development • регуляція експресії генів • positive regulation of chemokine production • intestinal epithelial cell maturation • GO:0048552 regulation of catalytic activity • positive regulation of autophagy of mitochondrion • cardiac ventricle morphogenesis • response to muscle activity • epithelial cell differentiation involved in mammary gland alveolus development • visual learning • positive regulation of vascular endothelial growth factor receptor signaling pathway • negative regulation of bone mineralization • negative regulation of growth • response to hypoxia • positive regulation of endothelial cell proliferation • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • iris morphogenesis • mRNA transcription by RNA polymerase II • hypoxia-inducible factor-1alpha signaling pathway • vasculature development • regulation of cell population proliferation • neural crest cell migration • embryonic hemopoiesis • connective tissue replacement involved in inflammatory response wound healing • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • negative regulation of reactive oxygen species metabolic process • positive regulation of vascular endothelial growth factor production • elastin metabolic process • positive regulation of glycolytic process • oxygen homeostasis • GO:0072468 сигнальна трансдукція • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular iron ion homeostasis • camera-type eye morphogenesis • cellular response to hypoxia • cellular response to interleukin-1 • transcription by RNA polymerase II • protein deubiquitination • посттрансляційна модифікація • response to iron ion • negative regulation of gene expression • positive regulation of blood vessel endothelial cell migration • GO:1901313 positive regulation of gene expression • cytokine-mediated signaling pathway • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • Убіквітин-залежний протеоліз |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_181054 NM_001243084 NM_001530 |
| | NM_010431 NM_001313919 NM_001313920 |
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RefSeq (білок) | | NP_001230013 NP_001521 NP_851397 NP_001521.1 |
| | NP_001300848 NP_001300849 NP_034561 |
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Локус (UCSC) | Хр. 14: 61.7 – 61.75 Mb | Хр. 12: 73.95 – 73.99 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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