Молекулярна функція | • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • chromatin binding • histone demethylase activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • transcription factor binding • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • methylated histone binding • histone H3-tri/di/monomethyl-lysine-4 demethylase activity |
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Біологічний процес | • диференціація клітин • negative regulation of histone methylation • GO:0009373 regulation of transcription, DNA-templated • thymus development • GO:1901227 negative regulation of transcription by RNA polymerase II • spleen development • transcription, DNA-templated • stem cell differentiation • multicellular organism development • central nervous system development • negative regulation of gene expression, epigenetic • regulation of cell population proliferation • liver development • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of cell population proliferation • positive regulation of histone H3-K9 methylation • negative regulation of cardiac muscle hypertrophy • cellular response to leukemia inhibitory factor • negative regulation of cardiac muscle cell proliferation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • histone demethylation • ремоделювання хроматину • histone H3-K4 demethylation, trimethyl-H3-K4-specific |
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