TNFRSF1A |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1EXT, 1FT4, 1ICH, 1NCF, 1TNR | | |
Ідентифікатори |
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Символи | TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60, tumor necrosis factor receptor superfamily member 1A, TNF receptor superfamily member 1A |
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Зовнішні ІД | OMIM: 191190 MGI: 1314884 HomoloGene: 828 GeneCards: TNFRSF1A |
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Пов'язані генетичні захворювання |
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розсіяний склероз, primary biliary cholangitis, autosomal dominant familial periodic fever[1] |
Онтологія гена |
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Молекулярна функція | • GO:0001948, GO:0016582 protein binding • tumor necrosis factor-activated receptor activity • tumor necrosis factor binding • identical protein binding |
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Клітинна компонента | • integral component of membrane • комплекс Ґольджі • мембрана • Golgi membrane • receptor complex • клітинна мембрана • integral component of plasma membrane • extracellular region • cell surface • мітохондрія • membrane raft • міжклітинний простір • tumor necrosis factor receptor superfamily complex |
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Біологічний процес | • regulation of apoptotic process • prostaglandin metabolic process • defense response • positive regulation of ceramide biosynthetic process • positive regulation of inflammatory response • regulation of tumor necrosis factor-mediated signaling pathway • tumor necrosis factor-mediated signaling pathway • response to lipopolysaccharide • cellular response to mechanical stimulus • death-inducing signaling complex assembly • regulation of cell population proliferation • defense response to bacterium • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of I-kappaB kinase/NF-kappaB signaling • GO:0022415 viral process • I-kappaB kinase/NF-kappaB signaling • negative regulation of inflammatory response • regulation of establishment of endothelial barrier • extrinsic apoptotic signaling pathway via death domain receptors • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 сигнальна трансдукція • GO:0097285 апоптоз • inflammatory response • cell surface receptor signaling pathway • positive regulation of tyrosine phosphorylation of STAT protein • protein localization to plasma membrane • cytokine-mediated signaling pathway • aortic valve development • pulmonary valve development • negative regulation of extracellular matrix constituent secretion • negative regulation of cardiac muscle hypertrophy • positive regulation of apoptotic process involved in morphogenesis |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_001065 NM_001346091 NM_001346092 |
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RefSeq (білок) | | NP_001056 NP_001333020 NP_001333021 |
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Локус (UCSC) | Хр. 12: 6.33 – 6.34 Mb | Хр. 6: 125.33 – 125.34 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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