CD40 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1CZZ, 1D00, 1FLL, 1LB6, 3QD6, 5DMJ, 5IHL, 5DMI | | |
Ідентифікатори |
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Символи | CD40, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule |
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Зовнішні ІД | OMIM: 109535 MGI: 88336 HomoloGene: 954 GeneCards: CD40 |
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Пов'язані генетичні захворювання |
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ревматоїдний артрит, CD40 deficiency[1] |
Онтологія гена |
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Молекулярна функція | • GO:0003823, GO:0051635 antigen binding • signal transducer activity • GO:0001948, GO:0016582 protein binding • tumor necrosis factor-activated receptor activity • enzyme binding • ubiquitin protein ligase binding • protein domain specific binding • signaling receptor activity |
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Клітинна компонента | • цитоплазма • integral component of membrane • внутрішньоклітинна мембранна органела • мембрана • клітинна мембрана • integral component of plasma membrane • extracellular region • cell surface • CD40 receptor complex • екзосома • external side of plasma membrane • міжклітинний простір • neuronal cell body • varicosity |
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Біологічний процес | • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • positive regulation of interleukin-12 production • protein kinase B signaling • positive regulation of protein kinase C signaling • процес імунної системи • cellular calcium ion homeostasis • tumor necrosis factor-mediated signaling pathway • immune response-regulating cell surface receptor signaling pathway • platelet activation • multicellular organism development • B cell activation • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • response to lipopolysaccharide • B cell proliferation • cellular response to mechanical stimulus • positive regulation of endothelial cell apoptotic process • regulation of cell population proliferation • positive regulation of B cell proliferation • positive regulation of NF-kappaB transcription factor activity • defense response to virus • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • regulation of immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • apoptotic signaling pathway • positive regulation of isotype switching to IgG isotypes • cellular response to lipopolysaccharide • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • defense response to protozoan • response to bacterium • response to nutrient levels • response to cobalamin • response to interferon-gamma • cellular response to erythropoietin • cellular response to interleukin-1 • cellular response to tumor necrosis factor • response to peptide • inflammatory response • positive regulation of tyrosine phosphorylation of STAT protein • positive regulation of blood vessel endothelial cell migration • positive regulation of angiogenesis • GO:0034622 protein-containing complex assembly |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_001250 NM_001302753 NM_152854 NM_001322421 NM_001322422
| NM_001362758 |
| | NM_011611 NM_170702 NM_170703 NM_170704 |
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RefSeq (білок) | NP_001241 NP_001289682 NP_001309350 NP_001309351 NP_690593
| NP_001349687 |
| | NP_035741 NP_733803 NP_733804 NP_733805 |
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Локус (UCSC) | Хр. 20: 46.12 – 46.13 Mb | Хр. 2: 164.9 – 164.91 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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