LILRB1 |
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Наявні структури |
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PDB | Пошук для людей: PDBe RCSB | Список кодів PDB | 1G0X, 1P7Q, 1UFU, 1UGN, 1VDG, 3D2U, 4LL9, 4NO0 | | |
Ідентифікатори |
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Символи | LILRB1, CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB, leukocyte immunoglobulin like receptor B1 |
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Зовнішні ІД | OMIM: 604811 HomoloGene: 88463 GeneCards: LILRB1 |
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Онтологія гена |
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Молекулярна функція | • protein homodimerization activity • MHC class I receptor activity • SH2 domain binding • protein phosphatase 1 binding • HLA-A specific inhibitory MHC class I receptor activity • HLA-B specific inhibitory MHC class I receptor activity • MHC class I protein binding • amyloid-beta binding • GO:0001948, GO:0016582 protein binding • MHC class Ib receptor activity • MHC class Ib protein complex binding • MHC class Ib protein binding |
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Клітинна компонента | • цитоплазма • integral component of membrane • мембрана • клітинна мембрана • extracellular region • external side of plasma membrane |
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Біологічний процес | • negative regulation of endocytosis • dendritic cell differentiation • negative regulation of mononuclear cell proliferation • negative regulation of interferon-gamma production • адаптивна імунна відповідь • Fc receptor mediated inhibitory signaling pathway • negative regulation of osteoclast development • процес імунної системи • response to virus • receptor internalization • negative regulation of cell cycle • GO:0002719 negative regulation of cytokine production involved in immune response • negative regulation of serotonin secretion • T cell proliferation involved in immune response • negative regulation of alpha-beta T cell activation • negative regulation of T cell mediated cytotoxicity • positive regulation of cytolysis • negative regulation of T cell proliferation • GO:1901313 positive regulation of gene expression • defense response to virus • negative regulation of calcium ion transport • regulation of immune response • positive regulation of apoptotic process • negative regulation of natural killer cell mediated cytotoxicity • negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell • cellular response to lipopolysaccharide • immune response-inhibiting cell surface receptor signaling pathway • positive regulation of gamma-delta T cell activation involved in immune response • negative regulation of dendritic cell apoptotic process • negative regulation of dendritic cell differentiation • GO:0072468 сигнальна трансдукція • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of CD8-positive, alpha-beta T cell activation • positive regulation of defense response to virus by host • positive regulation of macrophage cytokine production |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | ENSG00000104972 ENSG00000276452 ENSG00000277134 ENSG00000274669 ENSG00000277807
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UniProt | | |
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RefSeq (мРНК) | NM_001081637 NM_001081638 NM_001081639 NM_001278398 NM_001278399
| NM_006669 NM_001388355 NM_001388356 NM_001388357 NM_001388358 |
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RefSeq (білок) | NP_001075106 NP_001075107 NP_001075108 NP_001265327 NP_001265328
| NP_006660 |
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Локус (UCSC) | Хр. 19: 54.62 – 54.64 Mb | н/д |
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PubMed search | [1] | н/д |
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Вікідані |
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