KIT |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 4U0I, 1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F, 4HVS, 4K94, 4K9E, 4PGZ, 2IUH | | |
Ідентифікатори |
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Символи | KIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase, MASTC, KIT proto-oncogene, receptor tyrosine kinase |
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Зовнішні ІД | OMIM: 164920 MGI: 96677 HomoloGene: 187 GeneCards: KIT |
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Пов'язані генетичні захворювання |
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piebaldism, gastrointestinal stromal tumor, гострий мієлоїдний лейкоз, indolent systemic mastocytosis, Telangiectasia macularis eruptiva perstans[1] |
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Реагує на сполуку |
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cediranib, crenolanib, linifanib, Масітиніб, Пазопаніб, semaxanib, сорафеніб, сунітиніб, іматиніб, Масітиніб, amuvatinib, enmd-981693, famitinib, MLN-518, imatinib mesylate[2] |
Онтологія гена |
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Молекулярна функція | • stem cell factor receptor activity • kinase activity • transmembrane receptor protein tyrosine kinase activity • ATP binding • GO:0019974 cytokine binding • protein kinase activity • зв'язування з іоном металу • transferase activity • protein homodimerization activity • protease binding • GO:0001948, GO:0016582 protein binding • protein tyrosine kinase activity • nucleotide binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • receptor tyrosine kinase • transmembrane signaling receptor activity • SH2 domain binding |
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Клітинна компонента | • цитоплазма • мембрана • cell-cell junction • cytoplasmic side of plasma membrane • cell surface • integral component of membrane • Акросома • external side of plasma membrane • mast cell granule • міжклітинний простір • клітинна мембрана • integral component of plasma membrane • receptor complex |
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Біологічний процес | • melanocyte migration • myeloid progenitor cell differentiation • positive regulation of MAP kinase activity • glycosphingolipid metabolic process • positive regulation of phospholipase C activity • hematopoietic stem cell migration • stem cell population maintenance • protein phosphorylation • T cell differentiation • Сперматогенез • cell chemotaxis • developmental pigmentation • melanocyte differentiation • positive regulation of Notch signaling pathway • lamellipodium assembly • cytokine-mediated signaling pathway • transmembrane receptor protein tyrosine kinase signaling pathway • melanocyte adhesion • lymphoid progenitor cell differentiation • spermatid development • erythrocyte differentiation • negative regulation of programmed cell death • protein autophosphorylation • mast cell degranulation • inflammatory response • positive regulation of MAPK cascade • myeloid leukocyte differentiation • male gonad development • фосфорилювання • positive regulation of DNA-binding transcription factor activity • epithelial cell proliferation • stem cell differentiation • detection of mechanical stimulus involved in sensory perception of sound • regulation of cell shape • ovarian follicle development • ectopic germ cell programmed cell death • pigmentation • Fc receptor signaling pathway • response to radiation • mast cell cytokine production • positive regulation of receptor signaling pathway via JAK-STAT • dendritic cell cytokine production • visual learning • actin cytoskeleton reorganization • megakaryocyte development • GO:0007243 intracellular signal transduction • somatic stem cell population maintenance • erythropoietin-mediated signaling pathway • Kit signaling pathway • positive regulation of cell migration • somatic stem cell division • mast cell chemotaxis • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of pseudopodium assembly • GO:1901313 positive regulation of gene expression • positive regulation of long-term neuronal synaptic plasticity • regulation of cell population proliferation • cellular response to thyroid hormone stimulus • positive regulation of cell population proliferation • embryonic hemopoiesis • regulation of developmental pigmentation • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • mast cell differentiation • digestive tract development • immature B cell differentiation • germ cell migration • GO:0072468 сигнальна трансдукція • mast cell proliferation • positive regulation of vascular associated smooth muscle cell differentiation • phosphatidylinositol phosphate biosynthetic process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of tyrosine phosphorylation of STAT protein • tongue development • response to cadmium ion • positive regulation of pyloric antrum smooth muscle contraction • regulation of bile acid metabolic process • positive regulation of small intestine smooth muscle contraction • positive regulation of colon smooth muscle contraction • positive regulation of protein kinase B signaling • кровотворення • negative regulation of signal transduction • диференціація клітин • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • hematopoietic progenitor cell differentiation • B cell differentiation |
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Джерела:Amigo / QuickGO | |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 4: 54.66 – 54.74 Mb | Хр. 5: 75.74 – 75.82 Mb |
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PubMed search | [3] | [4] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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