MAPT |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1I8H, 4GLR, 2ON9, 3OVL, 4E0M, 4E0N, 4E0O, 4FL5, 4NP8, 2MZ7, 4TQE, 4Y5I, 4Y32, 5DMG, 4Y3B, 5HF3, 5E2W, 5E2V | | |
Ідентифікатори |
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Символи | MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, microtubule associated protein tau, Tau proteins, tau-40 |
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Зовнішні ІД | OMIM: 157140 MGI: 97180 HomoloGene: 74962 GeneCards: MAPT |
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Пов'язані генетичні захворювання |
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interstitial lung disease, progressive supranuclear palsy, хвороба Паркінсона, Хвороба Піка, semantic dementia[1] |
Онтологія гена |
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Молекулярна функція | • apolipoprotein binding • SH3 domain binding • tubulin binding • GO:0001948, GO:0016582 protein binding • lipoprotein particle binding • enzyme binding • DNA binding • actin binding • microtubule binding • dynactin binding • receptor ligand activity • protein phosphatase 2A binding • Hsp90 protein binding • minor groove of adenine-thymine-rich DNA binding • double-stranded DNA binding • single-stranded DNA binding • RNA binding • protein kinase binding • protein-macromolecule adaptor activity • phosphatidylinositol binding • identical protein binding • protein homodimerization activity • sequence-specific DNA binding • chaperone binding • histone-dependent DNA binding • microtubule lateral binding • phosphatidylinositol bisphosphate binding |
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Клітинна компонента | • цитоплазма • cell body • cell projection • nuclear periphery • growth cone • neurofibrillary tangle • клітинна мембрана • tubulin complex • дендрит (нейробіологія) • cytoplasmic ribonucleoprotein granule • цитоскелет • клітинне ядро • гіалоплазма • мікротрубочка • microtubule associated complex • мембрана • nuclear speck • аксон • somatodendritic compartment • neuronal cell body • axon cytoplasm • extracellular region • внутрішньоклітинний • мітохондрія • microtubule cytoskeleton • axolemma • neuron projection • dendritic spine • main axon • membrane raft • glial cell projection |
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Біологічний процес | • generation of neurons • regulation of autophagy • regulation of microtubule polymerization • positive regulation of microtubule polymerization • positive regulation of axon extension • microtubule cytoskeleton organization • microglial cell activation • activation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0072468 сигнальна трансдукція • пам'ять • negative regulation of mitochondrial membrane potential • axonal transport of mitochondrion • cytoplasmic microtubule organization • neuron projection development • positive regulation of superoxide anion generation • negative regulation of kinase activity • cellular response to heat • astrocyte activation • intracellular distribution of mitochondria • synapse organization • regulation of calcium-mediated signaling • protein complex oligomerization • plus-end-directed organelle transport along microtubule • regulation of mitochondrial fission • negative regulation of mitochondrial fission • Аксоплазматичний транспорт • regulation of cellular response to heat • positive regulation of neuron death • positive regulation of protein localization to synapse • neurofibrillary tangle assembly • negative regulation of establishment of protein localization to mitochondrion • positive regulation of diacylglycerol kinase activity • regulation of response to DNA damage stimulus • internal protein amino acid acetylation • cell-cell signaling • response to lead ion • regulation of signaling receptor activity • negative regulation of gene expression • rRNA metabolic process • central nervous system neuron development • regulation of microtubule polymerization or depolymerization • regulation of chromosome organization • stress granule assembly • GO:0072353 cellular response to reactive oxygen species • microtubule polymerization • regulation of synaptic plasticity • axon development • regulation of microtubule cytoskeleton organization • supramolecular fiber organization • regulation of long-term synaptic depression • positive regulation of protein localization • negative regulation of tubulin deacetylation • amyloid fibril formation • cellular response to nerve growth factor stimulus • cellular response to brain-derived neurotrophic factor stimulus |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | ENSG00000186868 ENSG00000276155 ENSG00000277956 |
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UniProt | | |
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RefSeq (мРНК) | NM_001123066 NM_001123067 NM_001203251 NM_001203252 NM_005910
| NM_016834 NM_016835 NM_016841 NM_001377265 NM_001377266 NM_001377267 NM_001377268 |
| | NM_001038609 NM_010838 NM_001285454 NM_001285455 NM_001285456 |
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RefSeq (білок) | NP_001116538 NP_001116539 NP_001190180 NP_001190181 NP_005901
| NP_058518 NP_058519 NP_058525 NP_001364194 NP_001364195 NP_001364196 NP_001364197 |
| NP_001033698 NP_001272383 NP_001272384 NP_001272385 NP_034968
| NP_001390904 NP_001390905 NP_001390906 NP_001390907 NP_001390908 NP_001390909 NP_001390910 NP_001390911 NP_001390912 NP_001390913 NP_001390916 NP_001390919 NP_001390921 NP_001390923 NP_001390925 NP_001390927 NP_001390928 NP_001390931 NP_001390933 NP_001390934 NP_001390935 NP_001390939 NP_001390940 NP_001390941 NP_001390943 NP_001390944 NP_001390945 |
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Локус (UCSC) | Хр. 17: 45.89 – 46.03 Mb | Хр. 11: 104.23 – 104.33 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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