Ravuconazole
Chemical compound
- None
- 4-[2-[(2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
- 182760-06-1 Y
- 467825
- 411041 N
- 95YH599JWV
- CHEBI:143825
- ChEMBL294029 N
- 057176
- DTXSID40171329
- Interactive image
- C[C@@H](c1nc(-c2ccc(C#N)cc2)cs1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F
InChI
- InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1 N
- Key:OPAHEYNNJWPQPX-RCDICMHDSA-N N
Ravuconazole (codenamed BMS-207147 and ER-30346) is a potent triazole antifungal, the development of which was discontinued in 2007.[1] The drug has shown to have a similar spectrum of activity to voriconazole, with an increased half-life.[2] However, ravuconazole has limited activity against species of Fusarium, Scedosporium, and Zygomycetes.[3][4]
See also
- Albaconazole
- Fosravuconazole, a prodrug of ravuconazole
- Isavuconazole
References
- ^ "Ravuconazole". AdisInsight. Springer Nature Switzerland AG. Retrieved 12 November 2017.
- ^ Pasqualotto AC, Denning DW. "Ravuconazole". The Aspergillus Website. Retrieved 18 February 2010.
- ^ Pasqualotto AC, Thiele KO, Goldani LZ (February 2010). "Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole". Current Opinion in Investigational Drugs. 11 (2): 165–174. PMID 20112166.
- ^ Pfaller MA, Messer SA, Hollis RJ, Jones RN (April 2002). "Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance Program, 2000". Antimicrobial Agents and Chemotherapy. 46 (4): 1032–1037. doi:10.1128/AAC.46.4.1032-1037.2002. PMC 127116. PMID 11897586.
External links
- Media related to Ravuconazole at Wikimedia Commons
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