Cilofungin
![]() | |
Names | |
---|---|
IUPAC name N-[(11R,20R,21R,25S,26S)-6-[(1S,2S)-1,2-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis(1-hydroxyethyl)-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.09,13]heptacosan-18-yl]-4-(octyloxy)benzamide | |
Other names 1-[(4R,5R)-4,5-Dihydroxy-N2-[p-(octyloxy)benzoyl]-L-ornithine]echinocandin B[1] (4R,5R)-4,5-Dihydroxy-N2-[p-(octyloxy)benzoyl]-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-L-threonyl-(3S,4S)-3-hydroxy-4-methyl-L-proline cyclic (6→1)-peptide[1] | |
Identifiers | |
CAS Number |
|
3D model (JSmol) |
|
ChEMBL |
|
ChemSpider |
|
MeSH | Cilofungin |
PubChem CID |
|
UNII |
|
CompTox Dashboard (EPA) |
|
InChI
| |
| |
Properties | |
Chemical formula | C49H71N7O17 |
Molar mass | 1030.12474 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ![]() ![]() ![]() Infobox references |
Chemical compound
Cilofungin (INN)[1] is the first clinically applied member of the echinocandin family of antifungal drugs. It was derived from a fungus in the genus Aspergillus. It accomplishes this by interfering with an invading fungus' ability to synthesize the cell wall (specifically, it inhibits the synthesis of (1→3)-β-D-glucan).[2]
References
- ^ a b c "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names (Rec. INN): List 29" (PDF). World Health Organization.
- ^ Hudler, George (1998). Magical Mushrooms, Mischievous Molds. Princeton, New Jersey: Princeton University Press. pp. 112. ISBN 978-0-691-07016-2.
- v
- t
- e
membrane
Pyrimidine analogues/ thymidylate synthase inhibitors |
|
---|---|
Mitotic inhibitors |
|
Aminoacyl tRNA synthetase inhibitors |
|
- bromochlorosalicylanilide
- chlorophetanol
- chlorphenesin
- ciclopirox
- crystal violet
- dimazole
- ethylparaben
- haloprogin‡
- polynoxylin
- potassium iodide#
- salicylic acid
- selenium disulfide#
- sodium thiosulfate#
- sulbentine
- taurolidine
- ticlatone
- tolciclate
- tolnaftate
- tribromometacresol
- undecylenic acid
- Whitfield's ointment#
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
![]() | This antiinfective drug article is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e