Β-Naphthoflavone
Names | |
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IUPAC name Benzo[5,6]flavone | |
Systematic IUPAC name 3-Phenyl-1H-naphtho[2,1-b]pyran-1-one | |
Other names 5,6-Benzoflavone, BNF | |
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ECHA InfoCard | 100.025.417 |
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Properties | |
Chemical formula | C19H12O2 |
Molar mass | 272.303 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
β-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and as such is an inducer of such detoxification enzymes as cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs).[1] β-Naphthoflavone is a putative chemopreventive agent.[2]
See also
References
- ^ Chlouchi A, Girard C, Bonet A, Viollon-Abadie C, Heyd B, Mantion G, Martin H, Richert L (2007). "Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture". Planta Med. 73 (8): 742–7. doi:10.1055/s-2007-981548. PMID 17599282. S2CID 260281088.
- ^ Izzotti A, Bagnasco M, Cartiglia C, Longobardi M, Camoirano A, Tampa E, Lubet RA, De Flora S (2005). "Modulation of multigene expression and proteome profiles by chemopreventive agents". Mutat Res. 591 (1–2): 212–23. doi:10.1016/j.mrfmmm.2005.03.032. PMID 16083920.
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- Agonists: Arachidonic acid metabolites (e.g., lipoxin A4, prostaglandin G2)
- Dietary carotenoids
- Flutamide
- Halogenated aromatic hydrocarbons (e.g., polychlorinated dibenzodioxins (e.g., TCDD), dibenzofurans, biphenyls)
- ΙΤΕ
- Modified low-density lipoproteins
- Polycyclic aromatic hydrocarbons (e.g., 3-methylcholanthrene, benzo[a]pyrene, benzanthracenes, benzoflavones (e.g., β-naphthoflavone))
- Tapinarof (benvitimod)
- Tetrapyroles (e.g., bilirubin)
- Tryptophan derivatives (e.g., indigo dye, indirubin)
- Antagonists: 7-Ketocholesterol
- CH-223191
- Cyproterone acetate
- See also
- Receptor/signaling modulators
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