Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
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PDB rendering based on 1mgs. |
有效结构 | PDB | 直系同源检索:PDBe, RCSB | PDB查询代码列表 | 1MGS, 1MSG, 1MSH, 1ROD | | |
标识 |
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代号 | CXCL1; FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1 |
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扩展标识 | 遗传学:155730 鼠基因:3037818 同源基因:117693 GeneCards: CXCL1 Gene |
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基因本体论描述 | 分子功能 | · receptor binding · chemokine activity · enzyme activator activity · growth factor activity
| 细胞成分 | · extracellular region · extracellular space
| 生物过程 | · chemotaxis · inflammatory response · immune response · signal transduction · G-protein coupled receptor signaling pathway · nervous system development · cell proliferation · negative regulation of cell proliferation · actin cytoskeleton organization · intracellular signal transduction · positive regulation of catalytic activity
| Sources: Amigo / QuickGO | |
直系同源体 |
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物种 | 人类 | 小鼠 |
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Entrez | 2919 | 330122 |
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Ensembl | ENSG00000163739 | ENSMUSG00000029379 |
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UniProt | P09341 | Q6W5C0 |
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mRNA序列 | NM_001511 | NM_203320 |
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蛋白序列 | NP_001502 | NP_976065 |
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基因位置 | Chr 4: 74.74 – 74.74 Mb | Chr 5: 90.79 – 90.79 Mb |
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PubMed查询 | [1] | [2] |
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CXCL1(英語:Chemokine (C-X-C motif) ligand 1)是一小分子的细胞因子属于CXC趋化因子家族[1]。又被称作生长调节致癌基因α (Growth-regulated oncogene alpha, GROα)[1][2][3]。 趋化因子CXCL1是由巨噬细胞,中性粒细胞和上皮细胞表达的[4][5]。趋化因子CXCL1对中性粒细胞有细胞趋化作用[1]。CXCL1结合到趋化因子受体CXCR2上而起细胞趋化作用[6]。人类的CXCL1与许多CXC类的趋化因子基因相邻聚集在第四染色体上[7] 。CXCL1的主要作用包括新血管形成、炎症反应、伤口愈合[6]和肿瘤形成[2][3]。
参见
参考文献
- ^ 1.0 1.1 1.2 Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M. Neutrophil-activating properties of the melanoma growth-stimulatory activity. J Exp Med. 1990 May 1;171(5):1797-802.
- ^ 2.0 2.1 Anisowicz, A., Bardwell, L., Sager, R. Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc. Nat. Acad. Sci. 84: 7188-7192, 1987.
- ^ 3.0 3.1 Richmond, A., Thomas, H. G. (1988) Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution J. Cell. Biochem. 36,185-198
- ^ Iida N, Grotendorst GR. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol Cell Biol. 1990 Oct;10(10):5596-9.
- ^ Becker S, Quay J, Koren HS, Haskill JS. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol. 1994 Mar;266(3 Pt 1):L278-86.
- ^ 6.0 6.1 Devalaraja, R. M., Nanney, L. B., Du, J., Qian, Q., Yu, Y., Devalaraja, M. N., Richmond, A. (2000) Delayed wound healing in CXCR2 knockout mice J. Investig. Dermatol. 115,234-244
- ^ Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988 Jul;7(7):2025-33.
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| 按族分类 | |
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| 按临床 功能分类 | - 单核因子
- 淋巴因子
- Th1
- 干扰素-γ
- 淋巴毒素-α(英语:Lymphotoxin alpha)
- Th2
- IL4
- interleukin 5(英语:interleukin 5)
- interleukin 6(英语:interleukin 6)
- 白细胞介素-10
- interleukin 13(英语:interleukin 13)
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| 信号转导索引 |
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| 描述 | - 胞外
- 細胞表面受體(英语:Template:Cell surface receptors)
- 配体门控离子通道
- 酶联受體
- G蛋白偶聯受體
- 免疫球蛋白超家族(英语:Template:Immunoglobulin superfamily immune receptors)
- 整合素
- 神經肽受體
- 生長因子受體
- 细胞因子受體
- 胞內
- 受體蛋白(英语:Template:Signal transducing adaptor proteins)
- GTP-binding(英语:Template:GTP-binding protein regulators)
- MAP激酶
- 鈣信號
- 脂質系號
- 路徑
- hedgehog
- Wnt
- TGF-β
- MAPK ERK(英语:Template:MAPK ERK signaling pathway)
- notch(英语:Template:Notch signaling pathway)
- JAK-STAT
- 細胞凋亡
- hippo(英语:Template:Hippo signaling pathway)
- TLR
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