组织蛋白酶W |
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識別號 |
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别名 | CTSW;, LYPN, cathepsin W |
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外部ID | OMIM:602364 MGI:1338045 HomoloGene:37471 GeneCards:CTSW |
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基因位置(小鼠) |
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![小鼠19号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/260px-Ideogram_house_mouse_chromosome_19.svg.png) | 染色体 | 小鼠19号染色体[2] |
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| 基因座 | 19|19 A | 起始 | 5,515,071 bp[2] |
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终止 | 5,518,535 bp[2] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/8/8e/PBB_GE_CTSW_214450_at_fs.png/250px-PBB_GE_CTSW_214450_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • 肽酶活性 • cysteine-type endopeptidase activity • 半胱氨酸型肽酶活性 • 水解酶活性
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細胞組分 | • 溶酶体 • 膜 • platelet dense granule lumen • 細胞外區域 • 細胞外空間 • 内质网
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生物學過程 | • proteolysis involved in cellular protein catabolic process • 免疫反应 • 蛋白酶解 • platelet degranulation
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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蛋白序列 | | |
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基因位置(UCSC) | Chr 11: 65.88 – 65.88 Mb | Chr 19: 5.52 – 5.52 Mb |
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PubMed查找 | [3] | [4] |
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維基數據 |
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组织蛋白酶W(英语:Cathepsin W)是一种在人体中由CTSW基因编码的蛋白质。[5][6][7]
该基因编码的蛋白质是半胱氨酸组织蛋白酶肽酶C1家族的成员,是一种半胱氨酸蛋白酶组织蛋白酶,可能在T细胞溶细胞活性的机制或调节中具有特定功能。编码的蛋白质被发现与自然杀伤细胞和细胞毒性T细胞的内质网内的细胞膜有关。该基因的表达被白细胞介素2上调。[7]
参见
参考文献
- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000172543 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000024910 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Linnevers C, Smeekens SP, Brömme D. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. FEBS Lett. May 1997, 405 (3): 253–9. PMID 9108299. S2CID 45420314. doi:10.1016/S0014-5793(97)00118-X
. - ^ Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D. Genomic structure, chromosomal localization, and expression of human cathepsin W. Biochem Biophys Res Commun. Aug 1998, 248 (2): 255–61. PMID 9675123. doi:10.1006/bbrc.1998.8954.
- ^ 7.0 7.1 Entrez Gene: CTSW cathepsin W.
阅读
- Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504. - Meinhardt C, Peitz U, Treiber G, et al. Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene.. Biochem. Biophys. Res. Commun. 2004, 321 (4): 975–80. PMID 15358123. doi:10.1016/j.bbrc.2004.07.056.
- Zhang Z, Henzel WJ. Signal peptide prediction based on analysis of experimentally verified cleavage sites.. Protein Sci. 2005, 13 (10): 2819–24. PMC 2286551
. PMID 15340161. doi:10.1110/ps.04682504. - Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899
. - Buhling F, Kellner U, Guenther D, et al. Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract.. Biol. Chem. 2003, 383 (7–8): 1285–9. PMID 12437118. S2CID 23389714. doi:10.1515/BC.2002.144.
- Wex T, Bühling F, Wex H, et al. Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum.. J. Immunol. 2001, 167 (4): 2172–8. PMID 11490002. doi:10.4049/jimmunol.167.4.2172
. - Wex T, Levy B, Wex H, Brömme D. Human cathepsins W and F form a new subgroup of cathepsins that is evolutionary separated from the cathepsin B- and L-like cysteine proteases.. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 2000, 477: 271–80. ISBN 0-306-46383-0. PMID 10849754. doi:10.1007/0-306-46826-3_29.
- Brinkworth RI, Tort JF, Brindley PJ, Dalton JP. Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes.. Int. J. Biochem. Cell Biol. 2000, 32 (3): 373–84. PMID 10716634. doi:10.1016/S1357-2725(99)00129-6.
- Wex T, Levy B, Wex H, Brömme D. Human cathepsins F and W: A new subgroup of cathepsins.. Biochem. Biophys. Res. Commun. 1999, 259 (2): 401–7. PMID 10362521. doi:10.1006/bbrc.1999.0700.
- Brown J, Matutes E, Singleton A, et al. Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase.. Leukemia. 1998, 12 (11): 1771–81. PMID 9823953. doi:10.1038/sj.leu.2401164
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外部链接
- The MEROPS online database for peptidases and their inhibitors: C01.037[失效連結]
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| 胱天蛋白酶 | |
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| 来自果实 | |
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| 钙蛋白酶 | - CAPN1
- CAPN2
- CAPN3
- CAPN5
- CAPN6
- CAPN7
- CAPN8
- CAPN9
- CAPN10
- CAPN11
- CAPN12
- CAPN13
- CAPN14
- CAPNS1
- CAPNS2
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| 组织蛋白酶 | |
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| 其它 | - 梭菌蛋白酶
- 癌性促凝物质
- 分离酶(英语:Separase)
- Autophagin
- Cruzipain
- 3C样蛋白酶
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| EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3(英语:Template:Ligases CO CS and CN)/4/5-6 |
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| 活性 | |
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| 调节 | |
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| 分类 | |
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| 动力学 | - 酶动力学
- 伊迪-霍夫斯蒂图(英语:Eadie–Hofstee diagram)
- 哈尼斯-伍尔夫图(英语:Hanes–Woolf plot)
- 双倒数图
- 米氏动力学
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| 类型 | - EC1 氧化還原酶(列表(英语:List of EC numbers (EC 1)))
- EC2 轉移酶(列表(英语:List of EC numbers (EC 2)))
- EC3 水解酶(列表(英语:List of EC numbers (EC 3)))
- EC4 裂合酶(列表(英语:List of EC numbers (EC 4)))
- EC5 異構酶(列表(英语:List of EC numbers (EC 5)))
- EC6 連接酶(列表(英语:List of EC numbers (EC 6)))
- EC7 移位酶(英语:Translocase)(列表(英语:List of EC numbers (EC 7)))
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