CENTG1

Arf-GAP sa GTPazom, ANK ponavljanje i protein 2 sa PH domenom

PDB prikaz baziran na 2bmj.

Dostupne strukture

2BMJ, 2IWR, 2RLO

Identifikatori

Simboli

AGAP2; CENTG1; GGAP2; PIKE

Vanjski ID

OMIM: 605476 HomoloGene: 86815 GeneCards: AGAP2 Gene

Ontologija gena
Molekularna funkcija	• nucleotidno vezivanje • GTP vezivanje • aktivator dejstva ARF GTPaze • vezivanje zink jona • vezivanje metalnog jona
Celularna komponenta	• intraćelijski • nukleus • nukleolus • citoplazma • mitohondrija
Biološki proces	• prenos signala posredovan malom GTPazom • vođenje aksona • proteinski transport • regulacija aktivnosti ARF GTPaze • negativna regulacija proteinskog kataboličkog procesa • negativna regulacija neuronske apoptoze

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

116986

216439

Ensembl

ENSG00000135439

ENSMUSG00000025422

UniProt

Q99490

Q3UHD9

RefSeq (mRNA)

NM_001122772.2

NM_001033263.4

RefSeq (protein)

NP_001116244.1

NP_001028435.1

Lokacija (UCSC)

Chr 12:
58.12 - 58.14 Mb

Chr 10:
126.52 - 126.53 Mb

PubMed pretraga

[1]

[2]

CENTG1 (Arf-GAP sa GTPazom, ANK ponavljanje i protein 2 koji sadrži PH domen) je enzim koji je kod ljudi kodiran AGAP2 genom.^[1]

Interakcije

CENTG1 formira interakcije sa PIK3R1,^[2] HOMER1^[3] i EPB41L1.^[2]

Reference

^ „Entrez Gene: CENTG1 centaurin, gamma 1”.
^ ^а ^б Ye, K; Hurt K J (2000). „Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N”. Cell. UNITED STATES. 103 (6): 919—30. ISSN 0092-8674. PMID 11136977. doi:10.1016/S0092-8674(00)00195-1.
^ Rong, Rong; Ahn Jee-Yin (2003). „PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis”. Nat. Neurosci. United States. 6 (11): 1153—61. ISSN 1097-6256. PMID 14528310. doi:10.1038/nn1134.

Literatura

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Elkahloun AG; Krizman DB; Wang Z (1997). „Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.”. Genomics. 42 (2): 295—301. PMID 9192850. doi:10.1006/geno.1997.4727.
Ye K; Hurt KJ; Wu FY (2001). „Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N.”. Cell. 103 (6): 919—30. PMID 11136977. doi:10.1016/S0092-8674(00)00195-1.
Ye K; Aghdasi B; Luo HR (2002). „Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.”. Nature. 415 (6871): 541—4. PMID 11823862. doi:10.1038/415541a.
Nie Z; Stanley KT; Stauffer S (2003). „AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton.”. J. Biol. Chem. 277 (50): 48965—75. PMID 12388557. doi:10.1074/jbc.M202969200.
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Ota T; Suzuki Y; Nishikawa T (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
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Knobbe CB, Trampe-Kieslich A, Reifenberger G (2005). „Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas.”. Neuropathol. Appl. Neurobiol. 31 (5): 486—90. PMID 16150119. doi:10.1111/j.1365-2990.2005.00660.x.
Hu Y, Liu Z, Ye K (2006). „Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings.”. Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16853—8. PMC 1283830 . PMID 16263930. doi:10.1073/pnas.0507365102.
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Werden SJ; Barrett JW; Wang G (2007). „M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A.”. J. Virol. 81 (5): 2340—8. PMC 1865929 . PMID 17151107. doi:10.1128/JVI.01310-06.
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