Brinzolamid
![]() | |
Klinički podaci | |
---|---|
Drugs.com | Monografija |
Način primene | Oftalmički |
Farmakokinetički podaci | |
Poluvreme eliminacije | 111 dana |
Identifikatori | |
CAS broj | 138890-62-7 ![]() |
ATC kod | S01EC04 (WHO) |
PubChem | CID 68844 |
DrugBank | DB01194 ![]() |
ChemSpider | 62077 ![]() |
KEGG | C07760 ![]() |
ChEBI | CHEBI:3176 ![]() |
ChEMBL | CHEMBL220491 ![]() |
Hemijski podaci | |
Formula | C12H21N3O5S3 |
Molarna masa | 383,507 |
SMILES
| |
InChI
| |
Fizički podaci | |
Tačka topljenja | 131 °C (268 °F) |
Brinzolamid je organsko jedinjenje, koje sadrži 12 atoma ugljenika i ima molekulsku masu od 383,507 Da.[1][2][3][4][5][6][7]
Osobine
Osobina | Vrednost |
---|---|
Broj akceptora vodonika | 6 |
Broj donora vodonika | 2 |
Broj rotacionih veza | 7 |
Particioni koeficijent[8] (ALogP) | -0,8 |
Rastvorljivost[9] (logS, log(mol/L)) | -2,2 |
Polarna površina[10] (PSA, Å2) | 163,8 |
Reference
- ^ Ermis SS, Ozturk F, Inan UU: Comparing the effects of travoprost and brinzolamide on intraocular pressure after phacoemulsification. Eye. 2005 Mar;19(3):303-7. PMID 15258611
- ^ Iester M, Altieri M, Michelson G, Vittone P, Traverso CE, Calabria G: Retinal peripapillary blood flow before and after topical brinzolamide. Ophthalmologica. 2004 Nov-Dec;218(6):390-6. PMID 15564757
- ^ Kaup M, Plange N, Niegel M, Remky A, Arend O: Effects of brinzolamide on ocular haemodynamics in healthy volunteers. Br J Ophthalmol. 2004 Feb;88(2):257-62. PMID 14736787
- ^ Iester M: Brinzolamide ophthalmic suspension: a review of its pharmacology and use in the treatment of open angle glaucoma and ocular hypertension. Clin Ophthalmol. 2008 Sep;2(3):517-23. PMID 19668749
- ^ DeSantis L: Preclinical overview of brinzolamide. Surv Ophthalmol. 2000 Jan;44 Suppl 2:S119-29. PMID 10665514
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889
. PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
- Brinzolamide
![]() | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |