Analogni pirimidini
Analogni pirimidini su antimetaboliti, koji imitiraju strukturu metaboličkih pirimidina.
Primeri
- 5-florouracil[1] (5FU) koji inhibira timidilat sintazu.[2]
- Floksuridin (FUDR)
- Citozin arabinozid (Citarabin)
- Pirimidin
- Florouracil
- Floksuridin
- Gemcitabin
Literatura
- ^ Huhtala A; Rönkkö S; Teräsvirta M; et al. (2009). „The effects of 5-fluorouracil on ocular tissues in vitro and in vivo after controlled release from a multifunctional implant”. Invest. Ophthalmol. Vis. Sci. 50 (5): 2216—23. PMID 19136700. doi:10.1167/iovs.08-3016.
- ^ Xi Y, Formentini A, Nakajima G, Kornmann M, Ju J (2008). „Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer”. Oncol. Rep. 19 (1): 257—62. PMID 18097604.
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Intracelularni hemoterapijski lekovi/Antineoplastični lekovi (L01)
(M faza)
Blokiranje formiranja microtubule | Vinca alkaloidi (Vinblastin, Vinkristin, Vinflunin, Vindesin, Vinorelbin) |
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Blokiranje rasformiranja microtubule | Taksani (Cabazitaksel, Docetaksel, Larotaksel, Ortataksel, Paclitaksel, Tesetaksel) • Epotiloni (Iksabepilon) |
DNK replikacije
Aminolevulinska acid/Metil aminolevulinat • Efaproksiral • Porfirin derivati (Porfimer natrijum, Talaporfin, Temoporfin, Verteporfin)
Inhibitori enzima | FI (Tipifarnib) • CDK inhibitori (Alvocidib, Seliciklib) • PrI (Bortezomib) • PhI (Anagrelid) • IMPDI (Tiazofurin) • LI (Masoprokol) • PARP inhibitor (Olaparib) • HDAC (Vorinostat, Romidepsin) |
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Receptorski antagonisti | |
Drugi/negrupisani | Amsakrin • Trabektedin • retinoidi (Alitretinoin, Tretinoin) • Arsen trioksid • asparaginski iscrpljivači (Asparaginaza/Pegaspargaza) • Celekoksib • Demekolcin • Elesklomol • Elsamitrucin • Etoglucid • Lonidamin • Lukanton • Mitoguazon • Mitotan • Oblimersen • mTOR inhibitori (Everolimus, Temsirolimus) |