Neuromedinski U receptor 2

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Neuromedinski U receptor 2
Identifikatori
SimboliNMUR2; FM4; NMU2R
Vanjski IDOMIM: 605108 MGI: 2441765 HomoloGene: 49618 IUPHAR: NMU2 GeneCards: NMUR2 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• aktivnost neuromedinskog U receptora
• receptorska aktivnost
• aktivnost intracelularnim kalcijumom aktiviranog hloridnog kanala
• GTP vezivanje
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • transport jona kalcijuma
• regulacija kontrakcija glatkih mišića
• prenos signala
• G-protein signalizacija, spregnuta sa IP3 sekundarnim glasnikom (aktivacija fosfolipaze C)
• elevacija koncentracije citosolnih jona kalcijuma
• neuropeptidni signalni put
• razvoj centralnog nervnog sistema
• način ishrane
• transmisija nervnog impulsa
• aktivacija kalcijum-zavisne fosfolipaze A2
• sekretorni put
• inozitol fosfat-posredovana signalizacija
• sekrecija arahidonske kiseline
Ortolozi
VrstaČovekMiš
Entrez56923216749
EnsemblENSG00000132911ENSMUSG00000037393
UniProtQ9GZQ4Q8BZ39
RefSeq (mRNA)NM_020167NM_153079
RefSeq (protein)NP_064552NP_694719
Lokacija (UCSC)Chr 5:
151.75 - 151.77 Mb		Chr 11:
55.87 - 55.88 Mb
PubMed pretraga[1][2]

Neuromedinski U receptor 2 je protein koji je kod ljudi kodiran NMUR2 genom.[1][2][3]

Vidi još

  • Neuromedinski U receptor

Literatura

  1. ↑ Tate CG, Grisshammer R (Jan 1997). „Heterologous expression of G-protein-coupled receptors”. Trends Biotechnol 14 (11): 426–30. DOI:10.1016/0167-7799(96)10059-7. PMID 8940772. 
  2. ↑ Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, Liu Q (Jul 2000). „Identification of receptors for neuromedin U and its role in feeding”. Nature 406 (6791): 70–4. DOI:10.1038/35017610. PMID 10894543. 
  3. ↑ „Entrez Gene: NMUR2 neuromedin U receptor 2”. 

Dodatna literatura

  • Hosoya M, Moriya T, Kawamata Y, et al. (2000). „Identification and functional characterization of a novel subtype of neuromedin U receptor.”. J. Biol. Chem. 275 (38): 29528–32. DOI:10.1074/jbc.M004261200. PMID 10887190. 
  • Raddatz R, Wilson AE, Artymyshyn R, et al. (2000). „Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.”. J. Biol. Chem. 275 (42): 32452–9. DOI:10.1074/jbc.M004613200. PMID 10899166. 
  • Shan L, Qiao X, Crona JH, et al. (2001). „Identification of a novel neuromedin U receptor subtype expressed in the central nervous system.”. J. Biol. Chem. 275 (50): 39482–6. DOI:10.1074/jbc.C000522200. PMID 11010960. 
  • Fernández Alvarez C, Debeljuk L, Díaz Rodríguez E, Díaz López B (2003). „Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin.”. Peptides 23 (9): 1617–23. DOI:10.1016/S0196-9781(02)00099-2. PMID 12217422. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Bhattacharyya S, Luan J, Farooqi IS, et al. (2004). „Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor.”. J. Endocrinol. 183 (1): 115–20. DOI:10.1677/joe.1.05830. PMID 15525579. 
  • Mori K, Miyazato M, Ida T, et al. (2005). „Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.”. EMBO J. 24 (2): 325–35. DOI:10.1038/sj.emboj.7600526. PMC 545815. PMID 15635449. 
  • Fang L, Zhang M, Li C, et al. (2006). „Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.”. Neurosci. Lett. 404 (1–2): 148–53. DOI:10.1016/j.neulet.2006.05.034. PMID 16781063. 

Spoljašnje veze

  • „Neuromedin U Receptors: NMU2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Neuropeptidni receptori
Hormonski receptori
Drugi
Opioidni receptori
Drugi neuropeptidni receptori
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)