Nervonska kiselina
Nervonska kiselina[1] | |||
---|---|---|---|
![]() | |||
IUPAC ime |
| ||
Drugi nazivi | cis-15-Tetrakozenoinska kiselina 24:1 cis, delta 9 ili 24:1 omega 9 | ||
Identifikacija | |||
CAS registarski broj | 506-37-6 ![]() | ||
PubChem[2][3] | 5281120 | ||
ChemSpider[4] | 4444565 ![]() | ||
KEGG[5] | C08323 | ||
ChEBI | 44247 | ||
ChEMBL[6] | CHEMBL1173379 ![]() | ||
Jmol-3D slike | Slika 1 | ||
| |||
| |||
Svojstva | |||
Molekulska formula | C24H46O2 | ||
Molarna masa | 366,62 g/mol | ||
Tačka topljenja | 42–43 °C | ||
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
Infobox references |
Nervonska kiselina je mononezasićena omega-9 masna kiselina. Utvrđeno je da je nervonska kiselina važna u biosintezi mijelina nervnih ćelija.[7] Ona je prisutana u sfingolipidima bele materije ljudskog mozga.
Nervonska kiselina se koristi u tretmanu poremećaja uzrokovanih demijelinacijom, kao što su adrenoleukodistrofija i multipla skleroza gde postoji snižen nivo nervonske kiseline u sfingolipidima.[8]
Reference
- ↑ Nervonic acid at Sigma-Aldrich
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ US Patent 6664406[mrtav link], Nervonic acid derivatives, their preparation and use
- ↑ WO/1996/005740[mrtav link], Nervonic Acid Compositions
Literatura
- Appelqvist (1976) Lipids in Cruciferae. In: Vaughan JG, Macleod AJ (Eds), The biology and the Chemistry of Cruciferae. Academic Press, London, UK, pp. 221-277.
- Sargent JR, Coupland K, Wilson R (1994). Nervonic Acid and Demyelinating Disease. Medical Hypothesese 42, pp. 237-242.
Spoljašnje veze
![]() | Portal Hemija |
- p
- r
- u