CLIC6

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Hloridni intracelularni kanal 6
Identifikatori
SimboliCLIC6; CLIC1L
Vanjski IDMGI: 2146607 HomoloGene: 43154 GeneCards: CLIC6 Gene
Ontologija gena
Molekularna funkcija • aktivnost naponom kontrolisanog jonskog kanala
• aktivnost naponom kontrolisanog hloridnog kanala
Celularna komponenta • cytoplasm
• ćelijska membrana
• integralno sa membranom
• kompleks hloridnog kanala
Biološki proces • jonski transport
Ortolozi
VrstaČovekMiš
Entrez54102209195
EnsemblENSG00000159212ENSMUSG00000022949
UniProtQ96NY7Q8BHB9
RefSeq (mRNA)NM_053277.1NM_172469.3
RefSeq (protein)NP_444507.1NP_766057.1
Lokacija (UCSC)Chr 21:
36.04 - 36.09 Mb		Chr 16:
92.49 - 92.54 Mb
PubMed pretraga[1][2]

Hloridni intracelularni kanal, protein 6 je protein koji je kod ljudi kodiran CLIC6 genom.[1][2] Ovaj gen je deo velikog trostrukog regiona nađenog na hromozomima 1, 6, i 21. Alternativno splajsovane transkriptne varijante su poznate, ali njihov biološki značaj nije poznat.[2]

Interakcije

CLIC6 formira interakcije sa dopaminskim receptorom D3.[3]

Reference

  1. ↑ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Jun 2000). „The DNA sequence of human chromosome 21”. Nature 405 (6784): 311–9. DOI:10.1038/35012518. PMID 10830953. 
  2. ↑ 2,0 2,1 „Entrez Gene: CLIC6 chloride intracellular channel 6”. 
  3. ↑ Griffon, Nathalie; Jeanneteau Freddy, Prieur Fanny, Diaz Jorge, Sokoloff Pierre (September 2003). „CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors”. Brain Res. Mol. Brain Res. (Netherlands) 117 (1): 47–57. DOI:10.1016/S0169-328X(03)00283-3. ISSN 0169-328X. PMID 14499480. 

Literatura

  • Singh H (2010). „Two decades with dimorphic Chloride Intracellular Channels (CLICs)”. Febs letters. 584 (10): 2112–21. DOI:10.1016/j.febslet.2010.03.013. PMID 20226783. 
  • Hillier LD, Lennon G, Becker M, et al. (1997). „Generation and analysis of 280,000 human expressed sequence tags”. Genome Res. 6 (9): 807–28. DOI:10.1101/gr.6.9.807. PMID 8889549. 
  • Strippoli P, D'Addabbo P, Lenzi L, et al. (2003). „Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q”. Mamm. Genome 13 (8): 456–62. DOI:10.1007/s00335-001-2157-0. PMID 12226712. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Scanlan MJ, Gout I, Gordon CM, et al. (2003). „Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression”. Cancer Immun. 1: 4. PMID 12747765. 
  • Griffon N, Jeanneteau F, Prieur F, et al. (2003). „CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors”. Brain Res. Mol. Brain Res. 117 (1): 47–57. DOI:10.1016/S0169-328X(03)00283-3. PMID 14499480. 
  • Friedli M, Guipponi M, Bertrand S, et al. (2004). „Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12”. Gene 320: 31–40. DOI:10.1016/S0378-1119(03)00830-8. PMID 14597386. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 

Vidi još

  • Hloridni kanal

Spoljašnje veze

  • MeSH CLIC6+protein,+human
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Ca2+: Kalcijumski kanal
L-tip/Cavα (1.1, 1.2, 1.3, 1.4) • N-tip/Cavα2.2 • P-tip/Cavα(2.1) • Q-tip/Cavα2.1 • R-tip/Cavα2.3 • T-tip/Cavα(3.1, 3.2, 3.3)
α2δ-podjedinice (1, 2) • β-podjedinice (β1, β2, β3, β4) • γ-podjedinice (γ1, γ2, γ3, γ4)
[Katjonski kanali sperme]] (1, 2, 3, 4) •Dvoporni kanal (1, 2)
Ligand-kontrolisani
Inozitol trisfosfatni receptor (1, 2, 3) • Rianodinski receptor (1, 2, 3)
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Na+: Natrijumski kanal
Naponom-kontrolisani
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) • Navβ (1, 2, 3, 4)
Konstitutivno aktivni
Epitelni Natrijumski kanal (α, β, γ, δ)
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K+: Kalijumski kanal
Naponom-kontrolisani
Kvα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8) • (2.1, 2.2) • (3.1, 3.2, 3.3, 3.4) • (4.1, 4.2, 4.3) • (5.1) • (6.1, 6.2, 6.3, 6.4)
Kvα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) • (8.1, 8.2) • (9.1, 9.2, 9.3) • (10.1, 10.2) • (11.1/hERG, 11.2, 11.3) • (12.1, 12.2, 12.3)
Kvβ (1, 2, 3) • KCNIP (1, 2, 3, 4) • minK/ISK • minK/ISK-sličan • MiRP (1, 2, 3) • Shaker gen
Kalcijumom-aktivirani
BK kanal (α1, β1, β2, β3, β4) • SK kanal (SK1, SK2, SK3, SK4) • KCa (1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1)
Unutrašnje-ispravljajući
KATP • Kir (1.1, 2.1, 2.2, 2.3, 2.4, 2.6) • GIRK/Kir (3.1, 3.2, 3.3, 3.4) • Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
Tandem pora domen
K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)
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Drugi
M+: TRP katjonski kanal
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (1, 2, 3) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Cl-: Hloridni kanal
ANO1 • Bestrofin (1, 2) • CFTR • CLCA (1, 2, 3, 4) • CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) • CLIC (1, 2, 3, 4, 5, 6, L1) • CLNS (1A, 1B)
α (1, 2, 3, 4) • β (1, 2, 3) • HCN (1, 2, 3, 4)
Porin
Akvaporin (1, 2, 3, 4, 5, 7, 8, 9) • Napon-zavisni anjonski kanal (1, 2, 3) • Generalna bakterijska porinska familija
Propusna veza
Koneksin: A (GJA1, GJA3, GJA4, GJA5, GJA8, GJA9, GJA10) • B (GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7) • C (GJC1, GJC2, GJC3) • D (GJD2, GJD3, GJD4) • E (GJE1)
Ineksin
Generalno
Ligandom-kontrolisani jonski kanal • Naponom-kontrolisani jonski kanal • Rastezanjem-aktivirani jonski kanal
vidi isto poremećaji
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr