CRHBP

editar

Corticotropin releasing hormone binding protein

Identificadores

CRHBP; CRF-BP; CRFBP

IDs externos

OMIM: 122559 MGI: 88497 HomoloGene: 1418 ChEMBL: 5930 GeneCards: CRHBP Gene

Ontologia do gene
Função molecular	•protein binding •peptide binding •corticotropin-releasing hormone binding
Componente celular	•extracellular space •intracellular •núcleo •secondary lysosome •multivesicular body •endoplasmic reticulum •Golgi apparatus •microtubule •secretory granule •dendrite •dense core granule •varicosity •perikaryon •axon terminus
Processo biológico	•synaptic transmission, dopaminergic •maternal aggressive behavior •resposta inflamatória •signal transduction •female pregnancy •behavior •learning or memory •hormone-mediated signaling pathway •cellular response to stress •cellular response to drug •cellular response to potassium ion •hormone metabolic process •regulated secretory pathway •behavioral response to ethanol •regulation of behavior •regulation of corticotropin secretion •negative regulation of corticotropin secretion •cellular response to calcium ion •cellular response to cocaine •cellular response to cAMP •cellular response to tumor necrosis factor •cellular response to estrogen stimulus •cellular response to estradiol stimulus •cellular response to gonadotropin-releasing hormone •negative regulation of corticotropin-releasing hormone receptor activity •regulation of N-methyl-D-aspartate selective glutamate receptor activity
Sources: Amigo / QuickGO

Padrões de expressão do ARN

Mais dados de expressão

Ortólogos

Espécies

Humano

Rato

Entrez

1393

12919

Ensembl

ENSG00000145708

ENSMUSG00000021680

UniProt

P24387

Q60571

RefSeq (mRNA)

NM_001882.3

NM_198408.3

RefSeq (proteína)

NP_001873.2

NP_940800.1

Localização (UCSC)

Chr 5:
76.25 – 76.28 Mb

Chr 13:
95.43 – 95.44 Mb

Busca PubMed

[1]

[2]

CRHBP (do inglês: corticotropin releasing hormone binding protein) é uma proteína que nos seres humanos é codificada pelo gene CRHBP.^[1]^[2]

A hormona libertadora da corticotrofina (CRH) é um potente estimulante da síntese e secreção de péptidos derivados de preopiomelanocortina. Apesar de as concentrações de CRH na circulação periférica humana serem normalmente baixas, ela aumenta ao longo da gravidez e cai rapidamente após o parto. A CRH plasmática maternal é provavelmente originária da placenta. O plasma humano contém uma proteína de ligação a CRH que inactiva a CRH e pode prevenir estimulação pituitária-adrenal inapropriada, na gravidez.^[1]

Referências

↑ ^a ^b «Entrez Gene: CRHBP corticotropin releasing hormone binding protein»
↑ Behan DP, Potter E, Lewis KA, Jenkins NA, Copeland N, Lowry PJ, Vale WW (Junho 1993). «Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)». Genomics. 16 (1): 63–8. PMID 8198617. doi:10.1006/geno.1993.1141 !CS1 manut: Nomes múltiplos: lista de autores (link)

Leitura de apoio

Behan DP, De Souza EB, Lowry PJ,; et al. (1996). «Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides.». Frontiers in neuroendocrinology. 16 (4): 362–82. PMID 8557170. doi:10.1006/frne.1995.1013 !CS1 manut: Nomes múltiplos: lista de autores (link)
Westphal NJ, Seasholtz AF (2006). «CRH-BP: the regulation and function of a phylogenetically conserved binding protein.». Front. Biosci. 11: 1878–91. PMID 16368564. doi:10.2741/1931
Potter E, Behan DP, Fischer WH,; et al. (1991). «Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins.». Nature. 349 (6308): 423–6. PMID 1846945. doi:10.1038/349423a0 !CS1 manut: Nomes múltiplos: lista de autores (link)
Behan DP, Linton EA, Lowry PJ (1989). «Isolation of the human plasma corticotrophin-releasing factor-binding protein.». J. Endocrinol. 122 (1): 23–31. PMID 2549150. doi:10.1677/joe.0.1220023 !CS1 manut: Nomes múltiplos: lista de autores (link)
Behan DP, Heinrichs SC, Troncoso JC,; et al. (1995). «Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease.». Nature. 378 (6554): 284–7. PMID 7477348. doi:10.1038/378284a0 !CS1 manut: Nomes múltiplos: lista de autores (link)
Vamvakopoulos NC, Sioutopoulou TO, Durkin SA,; et al. (1995). «Mapping the human corticotropin releasing hormone binding protein gene (CRHBP) to the long arm of chromosome 5 (5q11.2-q13.3).». Genomics. 25 (1): 325–7. PMID 7774945. doi:10.1016/0888-7543(95)80151-B !CS1 manut: Nomes múltiplos: lista de autores (link)
Maruyama K, Sugano S (1994). «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.». Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8
Fischer WH, Behan DP, Park M,; et al. (1994). «Assignment of disulfide bonds in corticotropin-releasing factor-binding protein.». J. Biol. Chem. 269 (6): 4313–6. PMID 8307998 !CS1 manut: Nomes múltiplos: lista de autores (link)
Donaldson CJ, Sutton SW, Perrin MH,; et al. (1996). «Cloning and characterization of human urocortin.». Endocrinology. 137 (5): 2167–70. PMID 8612563. doi:10.1210/en.137.5.2167 !CS1 manut: Nomes múltiplos: lista de autores (link)
Asakura H, Zwain IH, Yen SS (1997). «Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary.». J. Clin. Endocrinol. Metab. 82 (8): 2720–5. PMID 9253360. doi:10.1210/jc.82.8.2720 !CS1 manut: Nomes múltiplos: lista de autores (link)
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K,; et al. (1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.». Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3 !CS1 manut: Nomes múltiplos: lista de autores (link)
Strausberg RL, Feingold EA, Grouse LH,; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899 !CS1 manut: Nomes múltiplos: lista de autores (link)
Wetzka B, Sehringer B, Schäfer WR,; et al. (2004). «Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term.». Exp. Clin. Endocrinol. Diabetes. 111 (3): 154–61. PMID 12784189. doi:10.1055/s-2003-39778 !CS1 manut: Nomes múltiplos: lista de autores (link)
Claes S, Villafuerte S, Forsgren T,; et al. (2003). «The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden.». Biol. Psychiatry. 54 (9): 867–72. PMID 14573312. doi:10.1016/S0006-3223(03)00425-6 !CS1 manut: Nomes múltiplos: lista de autores (link)
Sehringer B, Zahradnik HP, Simon M,; et al. (2005). «mRNA expression profiles for corticotrophin-releasing hormone, urocortin, CRH-binding protein and CRH receptors in human term gestational tissues determined by real-time quantitative RT-PCR.». J. Mol. Endocrinol. 32 (2): 339–48. PMID 15072543. doi:10.1677/jme.0.0320339 !CS1 manut: Nomes múltiplos: lista de autores (link)
Gerhard DS, Wagner L, Feingold EA,; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504 !CS1 manut: Nomes múltiplos: lista de autores (link)
Herringa RJ, Roseboom PH, Kalin NH (2006). «Decreased amygdala CRF-binding protein mRNA in post-mortem tissue from male but not female bipolar and schizophrenic subjects.». Neuropsychopharmacology. 31 (8): 1822–31. PMID 16482088. doi:10.1038/sj.npp.1301038 !CS1 manut: Nomes múltiplos: lista de autores (link)