TNFAIP3 |
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사용 가능한 구조 |
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PDB | 동원체 검색: PDBe RCSB |
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PDB ID 코드 목록 |
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2EQF, 2EQG, 2VFJ, 3DKB, 3OJ3, 3OJ4, 3VUW, 3VUX, 3VUY, 3ZJD, 3ZJE, 3ZJF, 3ZJG, 4ZRH, 4ZS5 |
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식별자 |
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다른 이름 | TNFAIP3, A20, OTUD7C, TNFA1P2, AISBL, TNF alpha induced protein 3, AIFBL1 |
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외부 ID | OMIM: 191163 MGI: 1196377 HomoloGene: 4582 GeneCards: TNFAIP3 |
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유전자 위치 (인간) |
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| 염색체 | 6번 염색체[1] |
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| 자리 | 6q23.3 | 시작 | 137,867,214 bp[1] |
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끝 | 137,883,312 bp[1] |
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유전자 위치 (쥐) |
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| 염색체 | 10번 염색체 (쥐)[2] |
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| 자리 | 10 A3|10 8.08 cM | 시작 | 18,876,658 bp[2] |
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끝 | 18,891,405 bp[2] |
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RNA 발현 패턴 |
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Bgee | 인간 | 쥐(동원체) |
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최상위 발현 | - 대정맥
- mucosa of paranasal sinus
- 충수
- epithelium of nasopharynx
- 심장막
- mucosa of urinary bladder
- skin of thigh
- 가슴샘
- 림프절
- cartilage tissue
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| 최상위 발현 | - neural layer of retina
- 망막색소상피세포
- mesenteric lymph nodes
- 가슴샘
- epithelium of lens
- 과립구
- Paneth cell
- 공장
- left colon
- stroma of bone marrow
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| 추가 참조 발현 데이터 |
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BioGPS |
| 추가 참조 발현 데이터 |
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유전자 온톨로지 |
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분자 함수 | - DNA 결합
- cysteine-type peptidase activity
- zinc ion binding
- 금속 이온 결합
- ubiquitin-protein transferase activity
- protease binding
- protein self-association
- 펩티데이스 활성
- ligase activity
- kinase binding
- K63-linked polyubiquitin modification-dependent protein binding
- ubiquitin binding
- 단백질 결합
- catalytic activity
- thiol-dependent deubiquitinase
- 가수분해효소 활성
- identical protein binding
- Lys63-specific deubiquitinase activity
- transferase activity
| 세포 성분 | - 세포질
- 세포액
- 리소좀
- 엑소좀
- 세포핵
- intracellular membrane-bounded organelle
| 생물학적 과정 | - regulation of germinal center formation
- positive regulation of hepatocyte proliferation
- negative regulation of endothelial cell apoptotic process
- negative regulation of interleukin-1 beta production
- negative regulation of smooth muscle cell proliferation
- regulation of vascular wound healing
- B-1 B cell homeostasis
- protein K48-linked deubiquitination
- positive regulation of protein catabolic process
- negative regulation of cyclin-dependent protein serine/threonine kinase activity
- regulation of defense response to virus by host
- protein deubiquitination involved in ubiquitin-dependent protein catabolic process
- negative regulation of toll-like receptor 2 signaling pathway
- negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of interleukin-6 production
- negative regulation of B cell activation
- negative regulation of toll-like receptor 5 signaling pathway
- tolerance induction to lipopolysaccharide
- response to muramyl dipeptide
- negative regulation of chronic inflammatory response
- negative regulation of cell death
- negative regulation of I-kappaB kinase/NF-kappaB signaling
- 단백질분해과정
- establishment of protein localization to vacuole
- protein deubiquitination
- negative regulation of protein ubiquitination
- protein K48-linked ubiquitination
- protein K63-linked deubiquitination
- negative regulation of CD40 signaling pathway
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
- protein complex oligomerization
- protein K11-linked deubiquitination
- regulation of inflammatory response
- negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
- negative regulation of innate immune response
- negative regulation of osteoclast proliferation
- negative regulation of tumor necrosis factor production
- negative regulation of type I interferon production
- 물질대사
- inflammatory response
- response to molecule of bacterial origin
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of interleukin-2 production
- negative regulation of inflammatory response
- negative regulation of toll-like receptor 3 signaling pathway
- nucleotide-binding oligomerization domain containing signaling pathway
- cellular response to lipopolysaccharide
- negative regulation of toll-like receptor 4 signaling pathway
- negative regulation of bone resorption
- cellular response to hydrogen peroxide
- 세포자살
- protein ubiquitination
- cytoskeleton organization
- cell migration
- positive regulation of Wnt signaling pathway
- protein K29-linked deubiquitination
- protein K33-linked deubiquitination
| 출처: Amigo / QuickGO |
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동원체 |
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종 | 인간 | 쥐 |
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앙트레 | | |
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앙상블 | | |
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유니프롯 | | |
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RefSeq (mRNA) | |
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NM_001270507 NM_001270508 NM_006290 |
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RefSeq(단백질) | |
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NP_001257436 NP_001257437 NP_006281 |
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위치(UCSC) | Chr 6: 137.87 – 137.88 Mb | Chr 10: 18.88 – 18.89 Mb |
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PubMed 검색 | [3] | [4] |
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위키데이터 |
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