KCNH2 |
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사용 가능한 구조 |
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PDB | 동원체 검색: PDBe RCSB |
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PDB ID 코드 목록 |
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1BYW, 1UJL, 2L0W, 2L1M, 2L4R, 2LE7, 4HP9, 4HQA, 2N7G |
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식별자 |
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다른 이름 | KCNH2, ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1, potassium voltage-gated channel subfamily H member 2 |
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외부 ID | OMIM: 152427 MGI: 1341722 HomoloGene: 201 GeneCards: KCNH2 |
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유전자 위치 (인간) |
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| 염색체 | 7번 염색체[1] |
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| 자리 | 7q36.1 | 시작 | 150,944,961 bp[1] |
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끝 | 150,978,321 bp[1] |
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유전자 위치 (쥐) |
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| 염색체 | 5번 염색체 (쥐)[2] |
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| 자리 | 5 A3|5 10.94 cM | 시작 | 24,524,587 bp[2] |
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끝 | 24,556,602 bp[2] |
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RNA 발현 패턴 |
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Bgee | 인간 | 쥐(동원체) |
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최상위 발현 | - apex of heart
- right auricle
- 좌심실
- muscle layer of sigmoid colon
- right hemisphere of cerebellum
- 뇌하수체
- myocardium of left ventricle
- 뇌하수체 전엽
- right testis
- left testis
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| 최상위 발현 | - choroid plexus of fourth ventricle
- neural layer of retina
- 우심실
- 수정체
- central gray substance of midbrain
- epithelium of lens
- 숨뇌
- 심방
- 심실중격
- cerebellar cortex
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| 추가 참조 발현 데이터 |
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BioGPS | |
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유전자 온톨로지 |
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분자 함수 | - potassium channel activity
- protein homodimerization activity
- scaffold protein binding
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
- C3HC4-type RING finger domain binding
- voltage-gated ion channel activity
- ion channel activity
- 단백질 결합
- identical protein binding
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
- voltage-gated potassium channel activity
- phosphorelay sensor kinase activity
- ubiquitin protein ligase binding
- delayed rectifier potassium channel activity
- inward rectifier potassium channel activity
| 세포 성분 | - integral component of membrane
- 세포막
- voltage-gated potassium channel complex
- 세포막
- 세포 표면
- perinuclear region of cytoplasm
- inward rectifier potassium channel complex
- integral component of plasma membrane
| 생물학적 과정 | - membrane depolarization during action potential
- cardiac muscle contraction
- 신호전달
- regulation of membrane potential
- regulation of ion transmembrane transport
- ventricular cardiac muscle cell action potential
- 이온 수송
- potassium ion export across plasma membrane
- potassium ion transport
- membrane repolarization during action potential
- potassium ion homeostasis
- regulation of heart rate by hormone
- transmembrane transport
- potassium ion transmembrane transport
- positive regulation of potassium ion transmembrane transport
- phosphorelay signal transduction system
- regulation of membrane repolarization
- negative regulation of potassium ion transmembrane transport
- membrane repolarization during cardiac muscle cell action potential
- regulation of heart rate by cardiac conduction
- regulation of potassium ion transmembrane transport
- regulation of ventricular cardiac muscle cell membrane repolarization
- membrane repolarization during ventricular cardiac muscle cell action potential
- membrane repolarization
- negative regulation of potassium ion export across plasma membrane
- potassium ion import across plasma membrane
- cardiac conduction
| 출처: Amigo / QuickGO |
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동원체 |
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종 | 인간 | 쥐 |
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앙트레 | | |
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앙상블 | | |
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유니프롯 | | |
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RefSeq (mRNA) | |
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NM_000238 NM_001204798 NM_172056 NM_172057 |
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RefSeq(단백질) | |
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NP_000229 NP_001191727 NP_742053 NP_742054 |
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위치(UCSC) | Chr 7: 150.94 – 150.98 Mb | Chr 5: 24.52 – 24.56 Mb |
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PubMed 검색 | [3] | [4] |
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위키데이터 |
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