LMNA |
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Structure de la protéine LMNA. Basé sur l'identifiant PDB 1iFR. |
Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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1IFR, 1IVT, 1X8Y, 2XV5, 2YPT, 3GEF, 3V4Q, 3V4W, 3V5B |
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Identifiants |
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Aliases | LMNA |
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IDs externes | OMIM: 150330 MGI: 96794 HomoloGene: 41321 GeneCards: LMNA |
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Position du gène (Homme) |
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| Chr. | Chromosome 1 humain[1] |
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| Locus | 1q22 | Début | 156,082,573 bp[1] |
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Fin | 156,140,081 bp[1] |
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Position du gène (Souris) |
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| Chr. | Chromosome 3 (souris)[2] |
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| Locus | 3 F1|3 38.84 cM | Début | 88,387,454 bp[2] |
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Fin | 88,417,263 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - mamelon
- muqueuse gastrique
- skin of abdomen
- tendon of biceps brachii
- vésicule biliaire
- skin of leg
- Descending thoracic aorta
- stromal cell of endometrium
- tendon calcanéen
- left uterine tube
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| Fortement exprimé dans | - aorte ascendante
- valve aortique
- artère carotide externe
- artère carotide interne
- endothelial cell of lymphatic vessel
- lèvre
- condyle
- skin of back
- skin of external ear
- lactiferous gland
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| Plus de données d'expression de référence |
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BioGPS |
| Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - structural molecule activity
- liaison protéique
- identical protein binding
| Composant cellulaire | - Lamina
- cytosol
- nuclear speck
- lamin filament
- perinuclear region of cytoplasm
- Filament intermédiaire
- noyau
- matrice extracellulaire
- membrane nucléaire
- nucléoplasme
- enveloppe nucléaire
| Processus biologique | - regulation of cell migration
- organisation d'un noyau
- establishment or maintenance of microtubule cytoskeleton polarity
- negative regulation of release of cytochrome c from mitochondria
- negative regulation of extrinsic apoptotic signaling pathway
- muscle organ development
- regulation of protein localization to nucleus
- IRE1-mediated unfolded protein response
- mitotic nuclear membrane disassembly
- protein localization to nucleus
- mitotic nuclear membrane reassembly
- ventricular cardiac muscle cell development
- cellular response to hypoxia
- positive regulation of gene expression
- negative regulation of mesenchymal cell proliferation
- organisation de l'enveloppe nucléaire
- negative regulation of cell population proliferation
- regulation of telomere maintenance
- negative regulation of cardiac muscle hypertrophy in response to stress
- protein import into nucleus
- regulation of protein stability
- positive regulation of histone H3-K9 trimethylation
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001257374 NM_001282624 NM_001282625 NM_001282626 NM_005572
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NM_170707 NM_170708 |
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NM_001002011 NM_001111102 NM_019390 |
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RefSeq (protéine) | NP_001244303 NP_001269553 NP_001269554 NP_001269555 NP_005563
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NP_733821 NP_733822 |
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NP_001002011 NP_001104572 NP_062263 |
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Localisation (UCSC) | Chr 1: 156.08 – 156.14 Mb | Chr 3: 88.39 – 88.42 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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