IRF8 |
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Identifiants |
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Aliases | IRF8 |
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IDs externes | OMIM: 601565 MGI: 96395 HomoloGene: 1629 GeneCards: IRF8 |
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Position du gène (Homme) |
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| Chr. | Chromosome 16 humain[1] |
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| Locus | 16q24.1 | Début | 85,899,116 bp[1] |
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Fin | 85,922,606 bp[1] |
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Position du gène (Souris) |
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| Chr. | Chromosome 8 (souris)[2] |
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| Locus | 8 E1|8 70.05 cM | Début | 121,463,097 bp[2] |
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Fin | 121,483,433 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - monocyte
- ganglion lymphatique
- rate
- secondary oocyte
- appendice iléo-cæcal
- granulocyte
- sang
- epithelium of colon
- moelle osseuse
- rectum
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| Fortement exprimé dans | - Ileal epithelium
- ganglion mésentérique
- rate
- moelle osseuse
- tibiofemoral joint
- glande submandibulaire
- crypt of lieberkuhn of small intestine
- Jéjunum
- stroma of bone marrow
- subcutaneous adipose tissue
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| Plus de données d'expression de référence |
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BioGPS | | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - liaison ADN
- DNA-binding transcription factor activity
- liaison protéique
- transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Composant cellulaire | - cytosol
- nucléoplasme
- noyau
- cytoplasme
| Processus biologique | - myeloid cell differentiation
- regulation of transcription, DNA-templated
- response to bacterium
- positive regulation of interleukin-12 production
- interferon-gamma-mediated signaling pathway
- positive regulation of interferon-gamma production
- positive regulation of transcription initiation from RNA polymerase II promoter
- transcription, DNA-templated
- régulation positive de la transcription dépendante de l'ADN
- defense response to bacterium
- type I interferon signaling pathway
- réponse immunitaire
- phagocytose
- cellular response to lipopolysaccharide
- defense response to protozoan
- negative regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
- cellular response to interferon-gamma
- autophagie
- processus du système immunitaire
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_002163 NM_001363907 NM_001363908 |
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RefSeq (protéine) | |
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NP_002154 NP_001350836 NP_001350837 |
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Localisation (UCSC) | Chr 16: 85.9 – 85.92 Mb | Chr 8: 121.46 – 121.48 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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