FOXP3 |
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Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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3QRF, 4WK8 |
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Identifiants |
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Aliases | FOXP3 |
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IDs externes | OMIM: 300292 MGI: 1891436 HomoloGene: 8516 GeneCards: FOXP3 |
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Position du gène (Homme) |
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| Chr. | Chromosome X[1] |
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| Locus | Xp11.23 | Début | 49,250,438 bp[1] |
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Fin | 49,270,477 bp[1] |
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Position du gène (Souris) |
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| Chr. | X chromosome (souris)[2] |
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| Locus | X A1.1|X 3.41 cM | Début | 7,439,883 bp[2] |
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Fin | 7,461,484 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - gonade
- testicule
- tendon of biceps brachii
- ganglion lymphatique
- cæcum
- appendice iléo-cæcal
- sang
- tonsille
- vésicule biliaire
- granulocyte
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| Fortement exprimé dans | - urètre
- male urethra
- blastocyste
- embryon
- pharynx
- thymus
- méninges
- tail of embryo
- dentate gyrus of hippocampal formation granule cell
- neural layer of retina
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| Plus de données d'expression de référence |
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BioGPS |
| Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - sequence-specific DNA binding
- NF-kappaB binding
- transcription corepressor activity
- Fixation d'acide nucléique
- transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
- liaison protéique
- liaison d'histone déacétylase
- DNA-binding transcription factor activity
- NFAT protein binding
- liaison d'histone acétyltransférase
- liaison ion métal
- liaison ADN
- protein homodimerization activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
| Composant cellulaire | - noyau
- intracellulaire
- cytoplasme
- nucléoplasme
- complexe macromoléculaire
| Processus biologique | - negative regulation of cell population proliferation
- negative regulation of NF-kappaB transcription factor activity
- B cell homeostasis
- regulation of isotype switching to IgG isotypes
- myeloid cell homeostasis
- negative regulation of inflammatory response
- positive regulation of interleukin-4 production
- regulation of immunoglobulin production
- regulation of transcription by RNA polymerase II
- regulation of T cell anergy
- negative regulation of interleukin-6 production
- tolerance induction to self antigen
- regulation of transcription, DNA-templated
- negative regulation of DNA-binding transcription factor activity
- positive regulation of T cell tolerance induction
- negative regulation of immune response
- negative regulation of interferon-gamma production
- tolerance induction
- regulatory T cell differentiation
- régulation positive de la transcription dépendante de l'ADN
- negative regulation of interleukin-2 production
- positive regulation of histone acetylation
- negative regulation of interleukin-5 production
- negative regulation of chronic inflammatory response
- CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- positive regulation of transcription by RNA polymerase II
- negative regulation of activated T cell proliferation
- positive regulation of gene expression
- negative regulation of interleukin-4 production
- negative regulation of interleukin-10 production
- negative regulation of tumor necrosis factor production
- T cell homeostasis
- negative regulation of CREB transcription factor activity
- negative regulation of T-helper 17 cell differentiation
- T cell activation
- positive regulation of immature T cell proliferation in thymus
- positive regulation of regulatory T cell differentiation
- negative regulation of transcription by RNA polymerase II
- positive regulation of peripheral T cell tolerance induction
- positive regulation of transforming growth factor beta1 production
- negative regulation of transcription, DNA-templated
- negative regulation of lymphocyte proliferation
- negative regulation of histone acetylation
- negative regulation of interleukin-17 production
- response to virus
- negative regulation of histone deacetylation
- CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- negative regulation of T cell proliferation
- Remodelage de la chromatine
- cytokine production
- negative regulation of T cell cytokine production
- negative regulation of isotype switching to IgE isotypes
- T cell receptor signaling pathway
- positive regulation of T cell anergy
- transcription, DNA-templated
- T cell mediated immunity
- negative regulation of gene expression
- morphogenèse d'une structure anatomique
- regulation of Wnt signaling pathway
- regulation of regulatory T cell differentiation
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001199347 NM_001199348 NM_054039 |
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RefSeq (protéine) | | |
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NP_001186276 NP_001186277 NP_473380 |
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Localisation (UCSC) | Chr X: 49.25 – 49.27 Mb | Chr X: 7.44 – 7.46 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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