Ciclina T1

Función

Interacciones

• Aryl hydrocarbon receptor,^[4]​
• CDK9,^[2]​^[5]​^[6]​^[7]​^[8]​^[9]​^[10]​^[11]​^[12]​
• Granulin,^[6]​
• HEXIM1,^[5]​
• Myc,^[13]​
• NUFIP1,^[7]​ and
• Promyelocytic leukemia protein.^[14]​

Referencias

1. ↑ Wei P, Garber ME, Fang SM, Fischer WH, Jones KA (March 1998).
2. ↑ ^{a b} Peng J, Zhu Y, Milton JT, Price DH (April 1998).
3. ↑ "Entrez Gene: CCNT1 cyclin T1". 
4. ↑ Tian Y; Ke S; Chen M; Sheng T (noviembre de 2003). «Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter». J. Biol. Chem. 278 (45): 44041-8. PMID 12917420. doi:10.1074/jbc.M306443200. 
5. ↑ ^{a b} Michels AA; Nguyen VT; Fraldi A; Labas V; Edwards M; Bonnet F; Lania L; Bensaude O (julio de 2003). «MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner». Mol. Cell. Biol. 23 (14): 4859-69. PMC 162212. PMID 12832472. doi:10.1128/mcb.23.14.4859-4869.2003. 
6. ↑ ^{a b} Hoque M; Young TM; Lee CG; Serrero G; Mathews MB; Pe'ery T (marzo de 2003). «The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription». Mol. Cell. Biol. 23 (5): 1688-702. PMC 151712. PMID 12588988. doi:10.1128/mcb.23.5.1688-1702.2003. 
7. ↑ ^{a b} Cabart P; Chew HK; Murphy S (julio de 2004). «BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II». Oncogene 23 (31): 5316-29. PMID 15107825. doi:10.1038/sj.onc.1207684. 
8. ↑ Young TM; Wang Q; Pe'ery T; Mathews MB (septiembre de 2003). «The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription». Mol. Cell. Biol. 23 (18): 6373-84. PMC 193714. PMID 12944466. doi:10.1128/mcb.23.18.6373-6384.2003. 
9. ↑ Kiernan RE; Emiliani S; Nakayama K; Castro A; Labbé JC; Lorca T; Nakayama Ki K; Benkirane M (diciembre de 2001). «Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome». Mol. Cell. Biol. 21 (23): 7956-70. PMC 99964. PMID 11689688. doi:10.1128/MCB.21.23.7956-7970.2001. 
10. ↑ De Falco G; Bagella L; Claudio PP; De Luca A; Fu Y; Calabretta B; Sala A; Giordano A (enero de 2000). «Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation». Oncogene 19 (3): 373-9. PMID 10656684. doi:10.1038/sj.onc.1203305. 
11. ↑ Fu TJ; Peng J; Lee G; Price DH; Flores O (diciembre de 1999). «Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription». J. Biol. Chem. 274 (49): 34527-30. PMID 10574912. doi:10.1074/jbc.274.49.34527. 
12. ↑ Garber ME; Mayall TP; Suess EM; Meisenhelder J; Thompson NE; Jones KA (septiembre de 2000). «CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA». Mol. Cell. Biol. 20 (18): 6958-69. PMC 88771. PMID 10958691. doi:10.1128/mcb.20.18.6958-6969.2000. 
13. ↑ Kanazawa S; Soucek L; Evan G; Okamoto T; Peterlin BM (agosto de 2003). «c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis». Oncogene 22 (36): 5707-11. PMID 12944920. doi:10.1038/sj.onc.1206800. 
14. ↑ Marcello A; Ferrari A; Pellegrini V; Pegoraro G; Lusic M; Beltram F; Giacca M (mayo de 2003). «Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein». EMBO J. 22 (9): 2156-66. PMC 156077. PMID 12727882. doi:10.1093/emboj/cdg205.