ZNF76

Protein-coding gene in the species Homo sapiens
ZNF76
Identifiers
AliasesZNF76, D6S229E, ZNF523, Zfp523, zinc finger protein 76
External IDsOMIM: 194549; MGI: 2687278; HomoloGene: 2569; GeneCards: ZNF76; OMA:ZNF76 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ZNF76
Genomic location for ZNF76
Band6p21.31Start35,258,909 bp[1]
End35,295,985 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for ZNF76
Genomic location for ZNF76
Band17|17 A3.3Start28,396,103 bp[2]
End28,424,860 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • anterior pituitary

  • apex of heart

  • right adrenal cortex

  • left ovary

  • right uterine tube

  • right ovary

  • left adrenal cortex

  • right hemisphere of cerebellum
Top expressed in
  • interventricular septum

  • superior frontal gyrus

  • genital tubercle

  • neural layer of retina

  • primary visual cortex

  • tail of embryo

  • dentate gyrus of hippocampal formation granule cell

  • ventricular zone

  • Rostral migratory stream

  • olfactory epithelium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • DNA binding
  • nucleic acid binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • sequence-specific DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase III
  • transcription by RNA polymerase II
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7629

224656

Ensembl

ENSG00000065029

ENSMUSG00000024220

UniProt

P36508

Q8BMU0

RefSeq (mRNA)

NM_001292032
NM_003427

NM_172617
NM_001357995

RefSeq (protein)

NP_001278961
NP_003418

NP_766205
NP_001344924

Location (UCSC)Chr 6: 35.26 – 35.3 MbChr 17: 28.4 – 28.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 76 is a protein that in humans is encoded by the ZNF76 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065029 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024220 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ragoussis J, Senger G, Mockridge I, Sanseau P, Ruddy S, Dudley K, Sheer D, Trowsdale J (Dec 1992). "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11". Genomics. 14 (3): 673–9. doi:10.1016/S0888-7543(05)80167-3. PMID 1427894.
  6. ^ "Entrez Gene: ZNF76 zinc finger protein 76 (expressed in testis)".

Further reading

  • Prigge JR, Schmidt EE (2006). "Interaction of Protein Inhibitor of Activated STAT (PIAS) Proteins with the TATA-binding Protein, TBP". J. Biol. Chem. 281 (18): 12260–9. doi:10.1074/jbc.M510835200. PMC 2030495. PMID 16522640.
  • Zheng G, Yang YC (2006). "Acetylation and alternative splicing regulate ZNF76-mediated transcription". Biochem. Biophys. Res. Commun. 339 (4): 1069–75. doi:10.1016/j.bbrc.2005.11.122. PMID 16337145.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zheng G, Yang YC (2004). "ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation". J. Biol. Chem. 279 (41): 42410–21. doi:10.1074/jbc.M407287200. PMID 15280358.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Myslinski E, Krol A, Carbon P (1998). "ZNF76 and ZNF143 are two human homologs of the transcriptional activator Staf". J. Biol. Chem. 273 (34): 21998–2006. doi:10.1074/jbc.273.34.21998. PMID 9705341.


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