ZFYVE28

Protein-coding gene in the species Homo sapiens
ZFYVE28
Identifiers
AliasesZFYVE28, LST2, LYST2, zinc finger FYVE-type containing 28, lst-2
External IDsOMIM: 614176; MGI: 2684992; HomoloGene: 15119; GeneCards: ZFYVE28; OMA:ZFYVE28 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ZFYVE28
Genomic location for ZFYVE28
Band4p16.3Start2,269,582 bp[1]
End2,418,651 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for ZFYVE28
Genomic location for ZFYVE28
Band5|5 B2Start34,352,237 bp[2]
End34,445,793 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • granulocyte

  • right frontal lobe

  • Brodmann area 9

  • mucosa of transverse colon

  • anterior cingulate cortex

  • testicle

  • nucleus accumbens

  • body of stomach

  • prefrontal cortex
Top expressed in
  • neural layer of retina

  • cerebellar cortex

  • lumbar spinal ganglion

  • superior frontal gyrus

  • lobe of cerebellum

  • cerebellar vermis

  • piriform cortex

  • olfactory tubercle

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • phosphatidylinositol-3-phosphate binding
  • metal ion binding
Cellular component
  • cytoplasm
  • cytosol
  • endosome
  • early endosome membrane
  • membrane
Biological process
  • negative regulation of epidermal growth factor-activated receptor activity
  • negative regulation of epidermal growth factor receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57732

231125

Ensembl

ENSG00000159733

ENSMUSG00000037224

UniProt

Q9HCC9

Q6ZPK7

RefSeq (mRNA)
NM_001172656
NM_001172657
NM_001172658
NM_001172659
NM_001172660

NM_020972

NM_001015039

RefSeq (protein)
NP_001166127
NP_001166128
NP_001166129
NP_001166130
NP_001166131

NP_066023

NP_001015039

Location (UCSC)Chr 4: 2.27 – 2.42 MbChr 5: 34.35 – 34.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger FYVE-type containing 28 is a protein that in humans is encoded by the ZFYVE28 gene. [5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159733 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037224 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Zinc finger FYVE-type containing 28". Retrieved 2016-12-27.

Further reading

  • Mosesson Y, Chetrit D, Schley L, Berghoff J, Ziv T, Carvalho S, Milanezi F, Admon A, Schmitt F, Ehrlich M, Yarden Y (2009). "Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling". Dev. Cell. 16 (5): 687–98. doi:10.1016/j.devcel.2009.03.015. PMC 3356849. PMID 19460345.


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