ZFP91

Protein-coding gene in the species Homo sapiens
ZFP91
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2M9A

Identifiers
AliasesZFP91, DMS-8, DSM-8, PZF, ZFP-91, ZNF757, FKSG11, ZFP91 zinc finger protein, ZFP91 zinc finger protein, atypical E3 ubiquitin ligase, DSM8
External IDsMGI: 104854; HomoloGene: 43144; GeneCards: ZFP91; OMA:ZFP91 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ZFP91
Genomic location for ZFP91
Band11q12.1Start58,579,063 bp[1]
End58,621,550 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for ZFP91
Genomic location for ZFP91
Band19 A|19 8.73 cMStart12,744,384 bp[2]
End12,773,490 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibialis anterior muscle

  • mucosa of ileum

  • myocardium of left ventricle

  • deltoid muscle

  • cardiac muscle tissue of right atrium

  • cerebellar vermis

  • skin of arm

  • sperm

  • quadriceps femoris muscle

  • cartilage tissue
Top expressed in
  • ascending aorta

  • aortic valve

  • Rostral migratory stream

  • soleus muscle

  • gastrocnemius muscle

  • tibialis anterior muscle

  • plantaris muscle

  • extensor digitorum longus muscle

  • ankle

  • quadriceps femoris muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • nucleic acid binding
  • ubiquitin-protein transferase activity
  • transferase activity
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleolus
Biological process
  • protein K63-linked ubiquitination
  • activation of NF-kappaB-inducing kinase activity
  • protein ubiquitination
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80829

109910

Ensembl

ENSG00000186660

ENSMUSG00000024695

UniProt

Q96JP5

Q62511

RefSeq (mRNA)

NM_053023
NM_001197051

NM_053009

RefSeq (protein)

NP_001183980
NP_444251

NP_443735

Location (UCSC)Chr 11: 58.58 – 58.62 MbChr 19: 12.74 – 12.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 91 homolog is a protein that in humans is encoded by the ZFP91 gene.[5][6]

The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2 type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. In addition to the monocistronic transcript originating from this locus, a co-transcribed variant composed of ZFP91 and CNTF sequence has been identified. The monocistronic and co-transcribed variants encode distinct isoforms. The co-transcription of ZFP91 and CNTF has also been observed in mouse.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186660 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024695 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Unoki M, Okutsu J, Nakamura Y (May 2003). "Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia". Int J Oncol. 22 (6): 1217–23. doi:10.3892/ijo.22.6.1217. PMID 12738986.
  6. ^ a b "Entrez Gene: ZFP91 zinc finger protein 91 homolog (mouse)".

Further reading

  • Iuchi S (2001). "Three classes of C2H2 zinc finger proteins". Cell. Mol. Life Sci. 58 (4): 625–35. doi:10.1007/PL00000885. PMC 11146492. PMID 11361095. S2CID 6522993.
  • Grottke C, Mantwill K, Dietel M, et al. (2000). "Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs". Int. J. Cancer. 88 (4): 535–46. doi:10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V. PMID 11058868. S2CID 24030621.
  • Yu Y, Zhang C, Zhou G, et al. (2001). "Gene Expression Profiling in Human Fetal Liver and Identification of Tissue- and Developmental-Stage-Specific Genes through Compiled Expression Profiles and Efficient Cloning of Full-Length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening". Cell Cycle. 5 (6): 641–6. doi:10.4161/cc.5.6.2560. PMID 16582619.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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