ZC3H12A

Protein-coding gene in the species Homo sapiens

ZC3H12A

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3V32, 3V33, 3V34

Identifiers

Aliases

ZC3H12A, MCPIP, MCPIP1, dJ423B22.1, zinc finger CCCH-type containing 12A, Reg1, MCPIP-1

External IDs

OMIM: 610562; MGI: 2385891; HomoloGene: 11824; GeneCards: ZC3H12A; OMA:ZC3H12A - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p34.3	Start	37,474,580 bp^[1]
Band	1p34.3	End	37,484,377 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 D2.2	Start	125,012,216 bp^[2]
Band	4\|4 D2.2	End	125,021,633 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gallbladder

skin of abdomen

gastric mucosa

olfactory zone of nasal mucosa

skin of leg

cartilage tissue

granulocyte

left uterine tube

upper lobe of left lung

minor salivary glands

Top expressed in

granulocyte

blood

jejunum

intestinal villus

duodenum

esophagus

thymus

muscle of thigh

spleen

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	miRNA binding chromatin binding metal ion binding ribonuclease activity protein binding nuclease activity endonuclease activity mRNA binding hydrolase activity ribosome binding mRNA 3'-UTR binding mRNA 3'-UTR AU-rich region binding DNA binding RNA binding endoribonuclease activity exoribonuclease activity thiol-dependent deubiquitinase RNA stem-loop binding
Cellular component	cytoplasm nucleoplasm cytoskeleton nucleus extrinsic component of endoplasmic reticulum membrane endoplasmic reticulum rough endoplasmic reticulum membrane rough endoplasmic reticulum P-body membrane cytoplasmic ribonucleoprotein granule protein-containing complex
Biological process	positive regulation of p38MAPK cascade cellular response to virus cell differentiation positive regulation of cell death positive regulation of autophagy negative regulation of interleukin-6 production positive regulation of lipid storage negative regulation of macrophage activation cellular response to tumor necrosis factor negative regulation of gene expression positive regulation of angiogenesis negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of endothelial cell migration multicellular organism development protein deubiquitination positive regulation of gene expression positive regulation of reactive oxygen species metabolic process protein complex oligomerization angiogenesis regulation of gene expression positive regulation of protein import into nucleus negative regulation by host of viral genome replication negative regulation of tumor necrosis factor production positive regulation of miRNA catabolic process negative regulation of NF-kappaB transcription factor activity positive regulation of defense response to virus by host apoptotic process RNA phosphodiester bond hydrolysis, endonucleolytic immune system process negative regulation of muscle cell apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling transcription, DNA-templated positive regulation of fat cell differentiation positive regulation of transcription by RNA polymerase II nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay defense response to virus cellular response to glucose starvation nervous system development negative regulation of cytokine production involved in inflammatory response cellular response to sodium arsenite regulation of transcription, DNA-templated negative regulation of protein phosphorylation cellular response to ionomycin positive regulation of mRNA catabolic process cellular response to lipopolysaccharide cellular response to oxidative stress RNA phosphodiester bond hydrolysis negative regulation of nitric oxide biosynthetic process cellular response to interleukin-1 positive regulation of protein deubiquitination cellular response to chemokine inflammatory response 3'-UTR-mediated mRNA destabilization negative regulation of cardiac muscle contraction positive regulation of execution phase of apoptosis RNA phosphodiester bond hydrolysis, exonucleolytic cellular response to DNA damage stimulus immune response-activating signal transduction negative regulation of NIK/NF-kappaB signaling T cell receptor signaling pathway negative regulation of T-helper 17 cell differentiation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


80149


230738

Ensembl


ENSG00000163874


ENSMUSG00000042677

UniProt


Q5D1E8


Q5D1E7

RefSeq (mRNA)


NM_025079 NM_001323550 NM_001323551


NM_153159

RefSeq (protein)


NP_001310479 NP_001310480 NP_079355


NP_694799

Location (UCSC)

Chr 1: 37.47 – 37.48 Mb

Chr 4: 125.01 – 125.02 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Zinc finger CCCH-type containing 12A is a protein in humans that is encoded by the ZC3H12A gene.^[5]

ZC3H12A (also known as MCPIP-1 and Regnase-1) is an MCP1 (CCL2; MIM 158105)-induced protein that plays an important role in cell differentiation, apoptosis and the regulation of inflammation.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163874 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042677 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Zinc finger CCCH-type containing 12A".