WAY-213,613
Chemical compound
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ECHA InfoCard | 100.212.988 |
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Formula | C16H13BrF2N2O4 |
Molar mass | 415.191 g·mol−1 |
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WAY-213,613 is a drug which acts as a reuptake inhibitor for the glutamate transporter subtype EAAT2, selective over other glutamate transporter subtypes and highly selective over metabotropic and ionotropic glutamate receptors.[1] It is used in scientific research into the function of the glutamate transporters.[2]
References
- ^ Dunlop J, McIlvain HB, Carrick TA, Jow B, Lu Q, Kowal D, et al. (October 2005). "Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2". Molecular Pharmacology. 68 (4): 974–82. doi:10.1124/mol.105.012005. PMID 16014807. S2CID 24207924.
- ^ Karatas-Wulf U, Koepsell H, Bergert M, Sönnekes S, Kugler P (July 2009). "Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells". Neuroscience. 161 (3): 794–805. doi:10.1016/j.neuroscience.2009.04.017. PMID 19364521. S2CID 23641405.
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Glutamate metabolism and transport modulators
EAATsTooltip Excitatory amino acid transporters |
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vGluTsTooltip Vesicular glutamate transporters |
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GAHTooltip Glutamine aminohydrolase (glutaminase) |
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ASTTooltip Aspartate aminotransferase |
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ALTTooltip Alanine aminotransferase |
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GDHTooltip Glutamate dehydrogenase |
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GSTooltip Glutamine synthetase | |
GADTooltip Glutamate decarboxylase |
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See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators • GABA metabolism and transport modulators
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