VPS26B

Protein-coding gene in the species Homo sapiens
VPS26B
Identifiers
AliasesVPS26B, Pep8b, VPS26 retromer complex component B, VPS26, retromer complex component B
External IDsOMIM: 610027; MGI: 1917656; HomoloGene: 3601; GeneCards: VPS26B; OMA:VPS26B - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for VPS26B
Genomic location for VPS26B
Band11q25Start134,224,671 bp[1]
End134,247,788 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for VPS26B
Genomic location for VPS26B
Band9|9 A4Start26,919,067 bp[2]
End26,941,361 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • skin of arm

  • ganglionic eminence

  • granulocyte

  • right frontal lobe

  • prefrontal cortex

  • skin of leg

  • Brodmann area 9

  • skin of abdomen

  • cingulate gyrus
Top expressed in
  • ascending aorta

  • aortic valve

  • granulocyte

  • Region I of hippocampus proper

  • subiculum

  • nucleus accumbens

  • supraoptic nucleus

  • cerebellar cortex

  • barrel cortex

  • olfactory tubercle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • retromer complex
  • late endosome
  • early endosome
  • membrane
  • retromer, cargo-selective complex
  • endosome
  • cytosol
  • phagocytic vesicle
Biological process
  • protein transport
  • retrograde transport, endosome to Golgi
  • regulation of macroautophagy
  • intracellular protein transport
  • cellular response to interferon-gamma
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

112936

69091

Ensembl

ENSG00000151502

ENSMUSG00000031988

UniProt

Q4G0F5

Q8C0E2

RefSeq (mRNA)

NM_052875

NM_178027

RefSeq (protein)

NP_443107
NP_443107.1

NP_821170

Location (UCSC)Chr 11: 134.22 – 134.25 MbChr 9: 26.92 – 26.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vacuolar protein sorting 26 homolog B (S. pombe) is a protein in humans that is encoded by the VPS26B gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151502 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031988 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Vacuolar protein sorting 26 homolog B (S. pombe)".

Further reading

  • Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI (December 2000). "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes". Mol. Biol. Cell. 11 (12): 4105–16. doi:10.1091/mbc.11.12.4105. PMC 15060. PMID 11102511.
  • Kerr MC, Bennetts JS, Simpson F, Thomas EC, Flegg C, Gleeson PA, Wicking C, Teasdale RD (November 2005). "A novel mammalian retromer component, Vps26B". Traffic. 6 (11): 991–1001. doi:10.1111/j.1600-0854.2005.00328.x. PMID 16190980. S2CID 31954489.


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