USP39

Protein-coding gene in the species Homo sapiens
USP39
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3JCR

Identifiers
AliasesUSP39, 65K, HSPC332, SAD1, SNRNP65, CGI-21, ubiquitin specific peptidase 39
External IDsOMIM: 611594; MGI: 107622; HomoloGene: 13183; GeneCards: USP39; OMA:USP39 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for USP39
Genomic location for USP39
Band2p11.2Start85,602,856 bp[1]
End85,649,283 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for USP39
Genomic location for USP39
Band6 C1|6 32.27 cMStart72,295,661 bp[2]
End72,322,167 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • ganglionic eminence

  • gastrocnemius muscle

  • granulocyte

  • muscle of thigh

  • monocyte

  • stromal cell of endometrium

  • muscle layer of sigmoid colon

  • upper lobe of left lung

  • right lung
Top expressed in
  • epiblast

  • ventricular zone

  • tail of embryo

  • spermatocyte

  • placenta

  • yolk sac

  • granulocyte

  • ganglionic eminence

  • genital tubercle

  • bone marrow
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • thiol-dependent deubiquitinase
  • zinc ion binding
  • metal ion binding
  • protein binding
Cellular component
  • spliceosomal complex
  • nucleus
  • nucleoplasm
  • U4/U6 x U5 tri-snRNP complex
Biological process
  • protein deubiquitination
  • mRNA splicing, via spliceosome
  • cell cycle
  • mRNA processing
  • RNA splicing
  • cell division
  • spliceosomal complex assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10713

28035

Ensembl

ENSG00000168883

ENSMUSG00000056305

UniProt

Q53GS9

Q3TIX9

RefSeq (mRNA)

NM_001256725
NM_001256726
NM_001256727
NM_001256728
NM_006590

NM_138592

RefSeq (protein)

NP_001243654
NP_001243655
NP_001243656
NP_001243657
NP_006581

NP_613058

Location (UCSC)Chr 2: 85.6 – 85.65 MbChr 6: 72.3 – 72.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

U4/U6.U5 tri-snRNP-associated protein 2 is a protein that in humans is encoded by the USP39 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168883 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056305 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ "Entrez Gene: USP39 ubiquitin specific peptidase 39".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Lygerou Z, Christophides G, Séraphin B (1999). "A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing". Mol. Cell. Biol. 19 (3): 2008–20. doi:10.1128/mcb.19.3.2008. PMC 83994. PMID 10022888.
  • Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–713. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  • Makarova OV, Makarov EM, Lührmann R (2001). "The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes". EMBO J. 20 (10): 2553–2563. doi:10.1093/emboj/20.10.2553. PMC 125249. PMID 11350945.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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