UCN2

Protein-coding gene in the species Homo sapiens

UCN2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2RMG, 3N95

Identifiers

Aliases

UCN2, SRP, UCN-II, UCNI, UR, URP, urocortin 2

External IDs

OMIM: 605902; MGI: 2176375; HomoloGene: 50048; GeneCards: UCN2; OMA:UCN2 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p21.31	Start	48,561,718 bp^[1]
Band	3p21.31	End	48,563,781 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 F2	Start	108,815,078 bp^[2]
Band	9\|9 F2	End	108,816,232 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

testicle

skin of abdomen

skin of leg

olfactory zone of nasal mucosa

vagina

prostate

minor salivary glands

ectocervix

tibial nerve

Top expressed in

saccule

otic vesicle

otic placode

blastocyst

embryo

muscle of thigh

morula

esophagus

skin of external ear

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	hormone binding G protein-coupled receptor binding corticotropin-releasing hormone receptor 2 binding hormone activity corticotropin-releasing hormone receptor binding
Cellular component	extracellular region extracellular space intracellular anatomical structure
Biological process	digestion cellular response to nutrient levels regulation of signaling receptor activity response to stress adenylate cyclase-activating G protein-coupled receptor signaling pathway hormone-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


90226


171530

Ensembl


ENSG00000145040


ENSMUSG00000049699

UniProt


Q96RP3


Q99ML8

RefSeq (mRNA)


NM_033199


NM_145077

RefSeq (protein)


NP_149976


NP_659543

Location (UCSC)

Chr 3: 48.56 – 48.56 Mb

Chr 9: 108.82 – 108.82 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Urocortin-2 is a protein that in humans is encoded by the UCN2 gene.^[5]^[6]

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145040 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049699 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hsu SY, Hsueh AJ (Apr 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nat Med. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063. S2CID 22916906.
^ ^a ^b "Entrez Gene: UCN2 urocortin 2".

Hauger RL, Grigoriadis DE, Dallman MF, et al. (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacol. Rev. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952. S2CID 1572317.
Florio P, Torres PB, Torricelli M, et al. (2006). "Human endometrium expresses urocortin II and III messenger RNA and peptides". Fertil. Steril. 86 (6): 1766–70. doi:10.1016/j.fertnstert.2006.05.041. PMID 17074339.
Imperatore A, Florio P, Torres PB, et al. (2006). "Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes". Am. J. Obstet. Gynecol. 195 (1): 288–95. doi:10.1016/j.ajog.2005.12.048. PMID 16626608.
Isfort RJ, Wang F, Tscheiner M, et al. (2006). "Modifications of the human urocortin 2 peptide that improve pharmacological properties". Peptides. 27 (7): 1806–13. doi:10.1016/j.peptides.2006.01.003. PMID 16476507. S2CID 41513209.
Czimmer J, Million M, Taché Y (2006). "Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (3): G511–8. CiteSeerX 10.1.1.328.810. doi:10.1152/ajpgi.00289.2005. PMID 16223946. S2CID 10157248.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chang CL, Hsu SY (2005). "Ancient evolution of stress-regulating peptides in vertebrates". Peptides. 25 (10): 1681–8. doi:10.1016/j.peptides.2004.05.022. PMID 15476935. S2CID 25716793.
Karteris E, Hillhouse EW, Grammatopoulos D (2004). "Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility". Endocrinology. 145 (2): 890–900. doi:10.1210/en.2003-1210. PMID 14592950.
Chanalaris A, Lawrence KM, Stephanou A, et al. (2004). "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes". J. Mol. Cell. Cardiol. 35 (10): 1295–305. doi:10.1016/S0022-2828(03)00244-X. PMID 14519439.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lewis K, Li C, Perrin MH, et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. Bibcode:2001PNAS...98.7570L. doi:10.1073/pnas.121165198. PMC 34709. PMID 11416224.
Reyes TM, Lewis K, Perrin MH, et al. (2001). "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2843–8. Bibcode:2001PNAS...98.2843R. doi:10.1073/pnas.051626398. PMC 30227. PMID 11226328.