County | Location | mi[1] | km | Exit | Destinations | Notes |
Oconee | | 0.0 | 0.0 | |
US 76 west / SR 2 west – Clayton | Continuation from Georgia over the Chattooga River |
Westminster | 17.5 | 28.2 | | US 123 south (Toccoa Highway) – Toccoa | South end of US 123 overlap |
17.7 | 28.5 | | SC 183 north (Westminster Highway) – Walhalla | |
18.8 | 30.3 | | SC 24 east (Oak Highway) – Townville | |
| 21.7 | 34.9 | | SC 11 (Cherokee Foothills Scenic Highway) – Walhalla | |
Seneca | 25.8 | 41.5 | |
SC 28 west (Blue Ridge Boulevard) / SC 59 south (North 1st Street) – Walhalla, Seneca | West end of SC 28 overlap |
28.3 | 45.5 | | SC 130 (North 1st Street) – Salem, Seneca | |
| 32.7 | 52.6 | | SC 93 east – Clemson | To Clemson University |
Pickens | Clemson | 34.5 | 55.5 | | SC 133 north (College Avenue) – Six Mile, Clemson | To Clemson University and John C. Calhoun Home |
34.9 | 56.2 | | US 123 north (Tiger Boulevard) – Easley, Greenville | North end of US 123 overlap |
35.6 | 57.3 | | SC 93 (Old Greenville Highway) – Central, Norris | To Clemson University |
36.1 | 58.1 | |
SC 28 Bus. east (Pendleton Road) – Pendleton | |
Anderson | Pendleton | 36.1 | 58.1 | |
SC 28 Bus. west (Mechanic Street) – Pendleton | |
| 40.1 | 64.5 | | SC 187 south | |
| 46.0 | 74.0 | | I-85 – Atlanta, Greenville | |
| 47.7 | 76.8 | | SC 28 east – Starr, Abbeville | East end of SC 28 and west end of SC 28 Business overlap |
| 47.7 | 76.8 | | SC 28 east (Pearman Dairy Road) – Starr, Abbeville | East end of SC 28 and west end of SC 28 Business overlap |
Anderson | 48.5 | 78.1 | | US 178 west (Liberty Highway) – Liberty | West end of US 178 overlap |
49.8 | 80.1 | |
SC 28 Bus. east (Main Street) | East end of SC 28 Business overlap |
52.1 | 83.8 | |
US 29 Bus. north / SC 81 north (Greenville Street) | North end of US 29 Business and SC 81 overlap |
52.4 | 84.3 | | SC 24 (Whitner Street) | |
52.7 | 84.8 | | SC 81 south (Murray Street) – Starr | South end of US 29 Business and SC 81 overlap |
52.7 | 84.8 | | SC 28 Bus. (Main Street) – Abbeville, Augusta | |
54.0 | 86.9 | | US 29 south (Shockley Ferry Road) | South end of US 29 overlap |
54.6 | 87.9 | | US 29 north | North end of US 29 overlap |
| 58.2 | 93.7 | | SC 252 east – Honea Path | |
| 61.1 | 98.3 | | SC 413 – Iva | |
Belton | 63.6 | 102.4 | | SC 20 east (Brown Avenue) – Due West | East end of SC 20 overlap |
63.7 | 102.5 | | SC 20 west (Main Street) – Williamston | West end of SC 20 overlap |
Honea Path | 71.7 | 115.4 | | SC 252 west (Greer Street) – Anderson | West end of SC 252 overlap |
71.8 | 115.6 | | US 178 east (Church Street) – Due West, Greenwood | East end of US 178 overlap |
72.3 | 116.4 | | SC 252 east (Greer Street) – Ware Shoals | East end of SC 252 overlap |
Greenville | | 78.9 | 127.0 | | US 25 north (Augusta Road) – Greenville | North end of US 25 overlap |
Princeton | 80.1 | 128.9 | | US 25 south (Augusta Road) – Ware Shoals, Greenwood | South end of US 25 overlap |
Laurens | Hickory Tavern | 86.2 | 138.7 | | SC 101 north / Neely Ferry Road – Gray Court, Waterloo | |
Laurens | 94.0 | 151.3 | | SC 252 west – Ware Shoals | |
95.4 | 153.5 | |
US 76 Bus. east (Main Street) | |
96.7 | 155.6 | | SC 14 north (Church Street) – Greenville | North end of SC 14 overlap |
96.9 | 155.9 | | SC 14 south (Church Street) – Laurens, Greenwood | South end of SC 14 overlap |
97.7 | 157.2 | | US 221 (Harper Street) – Woodruff, Spartanburg, Greenwood | |
99.5 | 160.1 | |
US 76 Bus. west (Main Street) / SC 127 south – Laurens, Greenwood | |
Clinton | 105.9 | 170.4 | |
SC 56 Bus. / SC 72 Bus. (Broad Street) – Whitmire, Spartanburg, Greenwood, Saluda | |
107.7 | 173.3 | | SC 56 / SC 72 (Springdale Drive) – Whitmire, Spartanburg, Greenwood, Saluda | |
Joanna | 111.8 | 179.9 | | SC 66 (Whitmire Highway) – Whitmire, Chappells | |
Newberry | Kinards | 114.9 | 184.9 | | SC 560 west – Cross Hill | |
Newberry | 125.7 | 202.3 | | SC 121 (College Street) – Whitmire, Newberry | |
127.7 | 205.5 | | SC 34 east (Winnsboro Road) – Winnsboro | East end of SC 34 overlap |
127.9 | 205.8 | | SC 219 east (Main Street) – Pomaria | |
128.6 | 207.0 | | SC 34 west (Dixie Drive) – Greenwood | West end of SC 34 overlap |
Prosperity | 133.5 | 214.8 | | SC 391 south (Main Street) – Batesburg-Leesville | |
| 137.2 | 220.8 | | SC 773 north – Pomaria | |
Little Mountain | 141.6 | 227.9 | | SC 202 east – Pomaria | |
Richland | Ballentine | 154.3 | 248.3 | | SC 6 east (Dreher Shoals Road) – Lexington | |
Irmo | 155.5 | 250.3 | | US 176 west (Broad River Road) – Pomaria | West end of US 176 overlap |
158.3 | 254.8 | 101 |
I-26 west / US 176 east (Broad River Road) – Spartanburg, Columbia | West end of I-26 and east end of US 176 overlap Signed as exits 101A (west) and 101B (east) |
159.1 | 256.0 | 102 | SC 60 (Lake Murray Boulevard) – Irmo | Signed as exits 102A (west) and 102B (east) |
160.3 | 258.0 | 103 | Harbison Boulevard | |
Lexington | | 161.2 | 259.4 | 104 | Piney Grove Road | |
| 163.3 | 262.8 | 106 | St. Andrews Road | |
Richland | Columbia | 164.0 | 263.9 | 107 | I-20 – Augusta, Florence | Signed as exits 107A (west) and 107B (east) |
164.5 | 264.7 | 108A | Bush River Road | |
164.8 | 265.2 | 108B | I-26 east – Charleston, Airport | East end of I-26 and west end of I-126 overlap |
165.6 | 266.5 | | Colonial Life Boulevard to Bush River Road | Westbound exit and eastbound entrance |
166.7 | 268.3 | | Greystone Boulevard – Riverbanks Zoo | |
168.2 | 270.7 | |
US 21 south / US 176 east / US 321 south (Huger Street) | East end of I-126/US 176 and south end of US 21/US 321 overlap |
168.8 | 271.7 | | SC 48 east (Assembly Street) | |
168.9 | 271.8 | |
US 21 north / US 176 west / US 321 north (Main Street) – Chester, Rock Hill | US 176 and North end of US 21/US 321 and west end of US 176 overlap |
169.2 | 272.3 | |
SC 277 north (Bull Street) to I-20 / I-77 | |
169.7 | 273.1 | | SC 12 (Taylors Street) – Lexington | To Fort Jackson |
170.1 | 273.7 | |
US 1 south / US 378 west (Gervais Street) | South end of US 1 and west end of US 378 overlap |
171.0 | 275.2 | | US 1 north (Millwood Avenue) – Camden | North end of US 1 overlap |
172.4 | 277.5 | |
Devine Street west (US 21 Conn. west / US 76 Conn. west) to US 21 / US 321 / Millwood Avenue ends | Eastern terminus of US 21 Conn. and western segment of US 76 Conn., which use Devine Street |
173.3 | 278.9 | | SC 16 (Beltline Boulevard) | |
173.5 | 279.2 | | SC 760 east (Fort Jackson Boulevard) / Cross Hill Road north (US 76 Conn. west) – Fort Jackson | Eastern terminus of central segment of US 76 Conn.; western terminus of SC 760 |
| | | Rosewood Drive west / Wildcat Road east (US 76 Conn.) – Midlands Technical College Beltline Campus, Jim Hamilton–L.B. Owens Airport, Fort Jackson | Eastern segment of US 76 Conn. |
175.1 | 281.8 | | SC 262 east (Leesburg Road) – Leesburg | |
175.3 | 282.1 | | I-77 – Charleston, Charlotte | |
177.5 | 285.7 | | SC 768 west (Pineview Road) | |
Horrell Hill | 182.6 | 293.9 | | SC 769 east (Congaree Road) – Congaree | |
| 187.0 | 300.9 | | SC 764 east (Old Eastover Road) – Eastover | |
| 191.9 | 308.8 | | US 601 (McCords Ferry Road) – St. Matthews, Camden | |
| 194.2 | 312.5 | | SC 263 south (Vanboklen Road) – Eastover | |
Sumter | Stateburg | 201.4 | 324.1 | | SC 261 – Wedgefield, Horatio, Camden, Manning | |
Sumter | 203.0 | 326.7 | | SC 441 (Patriot Parkway) – Bishopville | |
203.4 | 327.3 | | Shaw Drive | To Shaw Air Force Base |
209.7 | 337.5 | | SC 120 west (Alice Drive) – Pinewood | |
210.2 | 338.3 | |
US 521 / US 76 Bus. east (Broad Street) – Sumter, Camden | |
212.4 | 341.8 | | US 15 (Main Street) – Bishopville | Exit ramps connect via frontage roads |
214.0 | 344.4 | | US 401 (Oswego Road) – Darlington | Exit ramps connect via frontage roads |
215.0 | 346.0 | |
US 378 east / US 76 Bus. west (Liberty Street) – Conway, Sumter | East end of US 378 overlap |
Mayesville | 222.3 | 357.8 | | SC 154 north (Lafayette Street) – St. Charles | |
Lee | | 225.0 | 362.1 | | SC 527 (Elliott Highway) – Elliott, Kingstree | |
Lynchburg | 231.9 | 373.2 | | SC 341 (Lynchburg Highway) – Bishopville, Lake City | |
Florence | | 239.6 | 385.6 | | SC 403 south (Cale Yarborough Highway) – Sardis | South end of SC 403 overlap |
Timmonsville | 241.1 | 388.0 | | SC 403 north (Brockington Street) – Hartsville | North end of SC 403 overlap |
Florence | 245.2 | 394.6 | | I-95 – Savannah, Fayetteville | |
249.2 | 401.0 | | SC 51 south (2nd Loop Road) – Pamplico | |
249.5 | 401.5 | |
David H. McLeod Boulevard west (US 76 Conn. west) to I-20 BS / I-20 / I-95 north – Columbia | Eastern terminus of US 76 Conn. |
| | | South Coit Street (US 52 Conn. north) | Western end of US 52 Conn. concurrency |
251.9 | 405.4 | | US 52 (South Irby Street) to I-95 – Charleston, Darlington, Downtown, County complex, Judicial center, McLeod Medical Center, Carolina Hospital | Eastern end of US 52 Conn. concurrency; southern terminus of US 52 Conn. |
| | | US 52 Truck (South Church Street) | |
| 256.7 | 413.1 | |
US 301 south (Freedom Boulevard) / SC 327 north (Williston Road) to I-20 / I-95 | South end of US 301 and north end of SC 327 overlap |
Mars Bluff | 258.4 | 415.9 | | SC 327 (Francis Marion Road) – Pamplico | South end of SC 327 overlap |
Marion | Pee Dee | 265.6 | 427.4 | | US 301 north – Dillon | North end of US 301 overlap; eastbound left exit and westbound entrance |
West Marion | 272.1 | 437.9 | |
SC 576 south to US 501 – Conway, Myrtle Beach, North Myrtle Beach | |
Marion | 273.6 | 440.3 | |
US 501 Bus. / SC 41 Alt. (Main Street) – Conway, Dillon | |
277.0 | 445.8 | | US 501 – Conway, Dillon | Interchange |
| | | | I-73 | Proposed interchange[2][3] |
Mullins | 282.5 | 454.6 | | SC 41 / SC 917 (Main Street) – Loris, Dillon | |
Nichols | 289.7 | 466.2 | | SC 9 north (Main Street) – Lake View, Dillon | North end of SC 9 overlap |
Horry | | 291.4 | 469.0 | | SC 9 south – North Myrtle Beach, Myrtle Beach | South end of SC 9 overlap |
| 297.9 | 479.4 | | US 76 east – Fair Bluff, Wilmington | Continuation into North Carolina |
1.000 mi = 1.609 km; 1.000 km = 0.621 mi
- Concurrency terminus
- Incomplete access
- Unopened
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