Protein-coding gene in the species Homo sapiens
TTI2 |
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Identifiers |
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Aliases | TTI2, C8orf41, MRT39, TELO2 interacting protein 2 |
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External IDs | OMIM: 614426; MGI: 2384576; HomoloGene: 11836; GeneCards: TTI2; OMA:TTI2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 8 (human)[1] |
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| Band | 8p12 | Start | 33,473,386 bp[1] |
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End | 33,513,185 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 8 (mouse)[2] |
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| Band | 8|8 A3 | Start | 31,640,343 bp[2] |
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End | 31,654,730 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - testicle
- ventricular zone
- gonad
- islet of Langerhans
- ganglionic eminence
- mucosa of transverse colon
- stromal cell of endometrium
- gastrocnemius muscle
- right testis
- left testis
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| Top expressed in | - otic vesicle
- otic placode
- primitive streak
- saccule
- submandibular gland
- lumbar subsegment of spinal cord
- tail of embryo
- gastrula
- granulocyte
- ventricular zone
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| More reference expression data |
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BioGPS | |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001102401 NM_001265581 NM_025115 NM_001330505 |
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NM_001112729 NM_001199988 NM_144927 |
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RefSeq (protein) | |
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NP_001095871 NP_001252510 NP_001317434 NP_079391 |
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Location (UCSC) | Chr 8: 33.47 – 33.51 Mb | Chr 8: 31.64 – 31.65 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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TELO2 interacting protein 2 is a protein that is encoded by the TTI2 gene in humans. [5]
Function
This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1.
The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000129696 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031577 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: TELO2 interacting protein 2". Retrieved 2016-12-14.
Further reading
- Hurov KE, Cotta-Ramusino C, Elledge SJ (2010). "A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability". Genes Dev. 24 (17): 1939–50. doi:10.1101/gad.1934210. PMC 2932975. PMID 20810650.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.