TRAPPC10

Protein-coding gene in the species Homo sapiens
TRAPPC10
Identifiers
AliasesTRAPPC10, EHOC-1, EHOC1, GT334, TMEM1, TRS130, TRS30, trafficking protein particle complex 10, trafficking protein particle complex subunit 10
External IDsOMIM: 602103; MGI: 1336209; HomoloGene: 37751; GeneCards: TRAPPC10; OMA:TRAPPC10 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for TRAPPC10
Genomic location for TRAPPC10
Band21q22.3Start44,012,309 bp[1]
End44,106,552 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow cells

  • granulocyte

  • rectum

  • appendix

  • monocyte

  • stromal cell of endometrium

  • epithelium of colon

  • transverse colon

  • sural nerve

  • islet of Langerhans
    n/a
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • sodium ion transmembrane transporter activity
  • protein binding
Cellular component
  • integral component of membrane
  • cytosol
  • Golgi apparatus
  • TRAPPII protein complex
  • Golgi membrane
  • TRAPP complex
Biological process
  • early endosome to Golgi transport
  • COPII vesicle coating
  • intra-Golgi vesicle-mediated transport
  • vesicle-mediated transport
  • sodium ion transport
  • sodium ion transmembrane transport
  • protein complex oligomerization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7109

216131

Ensembl

ENSG00000160218

ENSMUSG00000000374

UniProt

P48553

Q3TLI0

RefSeq (mRNA)

NM_001001723
NM_003274
NM_001351709

NM_001081055

RefSeq (protein)

NP_003265
NP_001338638

NP_001074524

Location (UCSC)Chr 21: 44.01 – 44.11 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Trafficking protein particle complex subunit 10 is a protein that in humans is encoded by the TRAPPC10 gene.[4][5]

The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi.

Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. Two transcript variants encoding different isoforms have been found for this gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160218 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Yamakawa K, Mitchell S, Hubert R, Chen XN, Colbern S, Huo YK, Gadomski C, Kim UJ, Korenberg JR (Sep 1995). "Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3". Hum Mol Genet. 4 (4): 709–16. doi:10.1093/hmg/4.4.709. PMID 7633421.
  5. ^ a b "Entrez Gene: TMEM1 transmembrane protein 1".

Further reading

  • Nagamine K, Kudoh J, Minoshima S, et al. (1996). "Isolation of cDNA for a novel human protein KNP-I that is homologous to the E. coli SCRP-27A protein from the autoimmune polyglandular disease type I (APECED) region of chromosome 21q22.3". Biochem. Biophys. Res. Commun. 225 (2): 608–16. doi:10.1006/bbrc.1996.1218. PMID 8753807.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Nagamine K, Kudoh J, Kawasaki K, et al. (1997). "Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3". Biochem. Biophys. Res. Commun. 235 (1): 185–90. doi:10.1006/bbrc.1997.6758. PMID 9196060.
  • Nagamine K, Kudoh J, Minoshima S, et al. (1997). "Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21". Genomics. 42 (3): 528–31. doi:10.1006/geno.1997.4761. PMID 9205129.
  • Lafrenière RG, Kibar Z, Rochefort DL, et al. (1997). "Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3". Gene. 198 (1–2): 313–21. doi:10.1016/S0378-1119(97)00333-8. PMID 9370297.
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
  • Gavin AC, Bösche M, Krause R, et al. (2002). "Functional organization of the yeast proteome by systematic analysis of protein complexes". Nature. 415 (6868): 141–7. Bibcode:2002Natur.415..141G. doi:10.1038/415141a. PMID 11805826. S2CID 4425555.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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