TPPP

Protein-coding gene in the species Homo sapiens
TPPP
Identifiers
AliasesTPPP, TPPP/p25, TPPP1, p24, p25, p25alpha, tubulin polymerization promoting protein
External IDsOMIM: 608773; MGI: 1920198; HomoloGene: 21389; GeneCards: TPPP; OMA:TPPP - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for TPPP
Genomic location for TPPP
Band5p15.33Start659,862 bp[1]
End693,352 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for TPPP
Genomic location for TPPP
Band13|13 C1Start74,157,526 bp[2]
End74,183,872 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • middle temporal gyrus

  • postcentral gyrus

  • internal globus pallidus

  • entorhinal cortex

  • inferior ganglion of vagus nerve

  • superior frontal gyrus

  • ventral tegmental area

  • superior vestibular nucleus

  • subthalamic nucleus
Top expressed in
  • primary motor cortex

  • ventral tegmental area

  • cingulate gyrus

  • piriform cortex

  • dentate gyrus

  • dentate gyrus of hippocampal formation granule cell

  • superior colliculus

  • lateral hypothalamus

  • subiculum

  • suprachiasmatic nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • microtubule binding
  • protein binding
  • tubulin binding
Cellular component
  • cytoplasm
  • perinuclear region of cytoplasm
  • myelin sheath
  • microtubule
  • cytoskeleton
  • nucleus
  • mitochondrion
  • cytosol
  • microtubule bundle
Biological process
  • microtubule polymerization
  • positive regulation of protein-containing complex assembly
  • positive regulation of protein polymerization
  • microtubule bundle formation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11076

72948

Ensembl

ENSG00000171368

ENSMUSG00000021573

UniProt

O94811

Q7TQD2

RefSeq (mRNA)

NM_007030

NM_182839

RefSeq (protein)

NP_008961

NP_878259

Location (UCSC)Chr 5: 0.66 – 0.69 MbChr 13: 74.16 – 74.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene.[5][6][7][8][9]

This protein has been linked to multiple sclerosis myelin lesions and CSF abnormalities in multiple sclerosis patients.[10]

This has also been linked to Parkinson's and Alzheimer's Disease[11][12]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171368 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021573 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T, Saito T (Apr 1999). "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3". J Hum Genet. 44 (2): 121–2. doi:10.1007/s100380050122. PMID 10083737.
  6. ^ Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J (Jul 2002). "Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations". Biochemistry. 41 (27): 8657–64. doi:10.1021/bi020140g. PMID 12093283.
  7. ^ Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH (Feb 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol Chem. 280 (7): 5703–15. doi:10.1074/jbc.M410409200. PMID 15590652.
  8. ^ Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J (Nov 2006). "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions". Biochemistry. 45 (46): 13818–26. doi:10.1021/bi061305e. PMID 17105200.
  9. ^ "Entrez Gene: TPPP brain-specific protein p25 alpha".
  10. ^ Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J (May 2011). "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". Biochem. Biophys. Res. Commun. 409 (1): 137–41. doi:10.1016/j.bbrc.2011.04.130. PMID 21565174.
  11. ^ Kovács, Gábor G.; László, Lajos; Kovács, János; Jensen, Poul Henning; Lindersson, Evo; Botond, Gergő; Molnár, Tamás; Perczel, András; Hudecz, Ferenc (2004-11-01). "Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies". Neurobiology of Disease. 17 (2): 155–162. doi:10.1016/j.nbd.2004.06.006. PMID 15474353. S2CID 42518910.
  12. ^ Kovács, Gábor G.; Gelpi, Ellen; Lehotzky, Attila; Höftberger, Romana; Erdei, Anna; Budka, Herbert; Ovádi, Judit (2006-11-23). "The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases". Acta Neuropathologica. 113 (2): 153–161. doi:10.1007/s00401-006-0167-4. ISSN 0001-6322. PMID 17123092. S2CID 28792202.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Martín CP, Vázquez J, Avila J, Moreno FJ (2002). "P24, a glycogen synthase kinase 3 (GSK 3) inhibitor". Biochim. Biophys. Acta. 1586 (1): 113–22. doi:10.1016/s0925-4439(01)00092-8. hdl:10261/252211. PMID 11781156.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Tirián L, Hlavanda E, Oláh J, et al. (2004). "TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation". Proc. Natl. Acad. Sci. U.S.A. 100 (24): 13976–81. doi:10.1073/pnas.2436331100. PMC 283531. PMID 14623963.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lehotzky A, Tirián L, Tökési N, et al. (2005). "Dynamic targeting of microtubules by TPPP/p25 affects cell survival". J. Cell Sci. 117 (Pt 25): 6249–59. doi:10.1242/jcs.01550. hdl:21.11116/0000-0002-1119-F. PMID 15564385.
  • DeGiorgis JA, Jaffe H, Moreira JE, et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.
  • Jämsä A, Bäckström A, Gustafsson E, et al. (2006). "Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells". Biochem. Biophys. Res. Commun. 345 (1): 324–31. doi:10.1016/j.bbrc.2006.04.032. PMID 16678793.
  • Skjoerringe T, Lundvig DM, Jensen PH, Moos T (2006). "P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain". J. Neurochem. 99 (1): 333–42. doi:10.1111/j.1471-4159.2006.04073.x. PMID 16879710. S2CID 86488870.
  • Oláh J, Tokési N, Vincze O, et al. (2006). "Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies". FEBS Lett. 580 (25): 5807–14. doi:10.1016/j.febslet.2006.09.037. PMID 17027006. S2CID 1513728.
  • Hlavanda E, Klement E, Kókai E, et al. (2007). "Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases". J. Biol. Chem. 282 (40): 29531–9. doi:10.1074/jbc.M703466200. hdl:2437/3435. PMID 17693641.
  • Song YJ, Lundvig DM, Huang Y, et al. (2007). "p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy". Am. J. Pathol. 171 (4): 1291–303. doi:10.2353/ajpath.2007.070201. PMC 1988878. PMID 17823288.


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