TMED2

Protein-coding gene
TMED2
Identifiers
AliasesTMED2, P24A, RNP24, p24, p24b1, p24beta1, transmembrane p24 trafficking protein 2
External IDsMGI: 3704329; HomoloGene: 55991; GeneCards: TMED2; OMA:TMED2 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for TMED2
Genomic location for TMED2
Band12q24.31Start123,584,533 bp[1]
End123,598,582 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parotid gland

  • corpus epididymis

  • pylorus

  • pericardium

  • trachea

  • caput epididymis

  • cardia

  • human penis

  • superior surface of tongue

  • Epithelium of choroid plexus
    n/a
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • transport vesicle
  • integral component of membrane
  • ER to Golgi transport vesicle membrane
  • Golgi apparatus
  • Golgi membrane
  • intracellular membrane-bounded organelle
  • Golgi cisterna membrane
  • zymogen granule membrane
  • membrane
  • endoplasmic reticulum
  • endoplasmic reticulum membrane
  • cytoplasmic vesicle membrane
  • cytoplasmic vesicle
  • COPI-coated vesicle
  • endoplasmic reticulum-Golgi intermediate compartment membrane
  • endoplasmic reticulum-Golgi intermediate compartment
  • COPI-coated vesicle membrane
  • COPII-coated ER to Golgi transport vesicle
Biological process
  • vesicle cargo loading
  • neural tube closure
  • maternal placenta development
  • embryonic placenta development
  • COPII vesicle coating
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • heart looping
  • positive regulation of gene expression
  • somitogenesis
  • Golgi organization
  • post-anal tail morphogenesis
  • embryonic morphogenesis
  • multicellular organism growth
  • in utero embryonic development
  • protein transport
  • negative regulation of GTPase activity
  • COPI coating of Golgi vesicle
  • labyrinthine layer blood vessel development
  • vesicle-mediated transport
  • somite rostral/caudal axis specification
  • intracellular protein transport
  • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
  • protein localization to plasma membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10959

100862175

Ensembl

ENSG00000086598

n/a

UniProt

Q15363

Q9R0Q3

RefSeq (mRNA)

NM_006815
NM_001321445

XM_003945446

RefSeq (protein)

NP_001308374
NP_006806

NP_062744
NP_001390182
NP_001390186

Location (UCSC)Chr 12: 123.58 – 123.6 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane emp24 domain-containing protein 2 is a protein that in humans is encoded by the TMED2 gene.[4][5]

Interactions

TMED2 has been shown to interact with GORASP1[6] and GORASP2.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000086598 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (July 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". The Journal of Biological Chemistry. 271 (29): 17183–9. doi:10.1074/jbc.271.29.17183. PMID 8663407.
  5. ^ "Entrez Gene: TMED2 transmembrane emp24 domain trafficking protein 2".
  6. ^ a b Barr FA, Preisinger C, Kopajtich R, Körner R (December 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". The Journal of Cell Biology. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.

Further reading

  • Fiedler K, Veit M, Stamnes MA, Rothman JE (September 1996). "Bimodal interaction of coatomer with the p24 family of putative cargo receptors". Science. 273 (5280): 1396–9. Bibcode:1996Sci...273.1396F. doi:10.1126/science.273.5280.1396. PMID 8703076. S2CID 13159384.
  • Gommel D, Orci L, Emig EM, Hannah MJ, Ravazzola M, Nickel W, Helms JB, Wieland FT, Sohn K (March 1999). "p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway". FEBS Letters. 447 (2–3): 179–85. doi:10.1016/S0014-5793(99)00246-X. PMID 10214941. S2CID 41832392.
  • Majoul I, Straub M, Hell SW, Duden R, Söling HD (July 2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET". Developmental Cell. 1 (1): 139–53. doi:10.1016/S1534-5807(01)00004-1. PMID 11703931.
  • Barr FA, Preisinger C, Kopajtich R, Körner R (December 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". The Journal of Cell Biology. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.
  • Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, Hauri HP (November 2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". The Journal of Biological Chemistry. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
  • Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P (April 2006). "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity". Nature. 440 (7088): 1208–12. Bibcode:2006Natur.440.1208C. doi:10.1038/nature04667. PMID 16641999. S2CID 4349251.
  • Luo W, Wang Y, Reiser G (October 2007). "p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking". The Journal of Biological Chemistry. 282 (41): 30246–55. doi:10.1074/jbc.M703205200. PMID 17693410.


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