TBCA

Protein-coding gene in the species Homo sapiens
TBCA
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1H7C

Identifiers
AliasesTBCA, tubulin folding cofactor A
External IDsOMIM: 610058; MGI: 107549; HomoloGene: 3388; GeneCards: TBCA; OMA:TBCA - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for TBCA
Genomic location for TBCA
Band5q14.1Start77,691,166 bp[1]
End77,868,780 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for TBCA
Genomic location for TBCA
Band13|13 C3Start94,925,418 bp[2]
End94,979,430 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right adrenal cortex

  • left adrenal gland

  • left adrenal cortex

  • ganglionic eminence

  • ventricular zone

  • left ovary

  • islet of Langerhans

  • anterior pituitary

  • gastric mucosa

  • tibial arteries
Top expressed in
  • cumulus cell

  • endocardial cushion

  • facial motor nucleus

  • supraoptic nucleus

  • medial ganglionic eminence

  • atrioventricular valve

  • mandibular prominence

  • maxillary prominence

  • abdominal wall

  • trigeminal ganglion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • chaperone binding
  • protein binding
  • beta-tubulin binding
  • RNA binding
Cellular component
  • cytoplasm
  • microtubule cytoskeleton
  • nucleolus
  • microtubule
  • cytoskeleton
  • extracellular exosome
Biological process
  • post-chaperonin tubulin folding pathway
  • tubulin complex assembly
  • protein folding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6902

21371

Ensembl

ENSG00000171530

ENSMUSG00000042043

UniProt

O75347

P48428

RefSeq (mRNA)

NM_004607
NM_001297738
NM_001297740

NM_009321

RefSeq (protein)

NP_001284667
NP_001284669
NP_004598

NP_033347

Location (UCSC)Chr 5: 77.69 – 77.87 MbChr 13: 94.93 – 94.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulin-specific chaperone A is a protein that in humans is encoded by the TBCA gene.[5][6][7]

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171530 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042043 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  6. ^ Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ (Sep 1996). "Pathway leading to correctly folded beta-tubulin". Cell. 86 (2): 287–96. doi:10.1016/S0092-8674(00)80100-2. PMID 8706133.
  7. ^ a b "Entrez Gene: TBCA tubulin folding cofactor A".

Further reading

  • Lewis SA, Tian G, Vainberg IE, Cowan NJ (1996). "Chaperonin-mediated folding of actin and tubulin". J. Cell Biol. 132 (1–2): 1–4. doi:10.1083/jcb.132.1.1. PMC 2120700. PMID 8567715.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Guasch A, Aloria K, Pérez R, et al. (2002). "Three-dimensional structure of human tubulin chaperone cofactor A". J. Mol. Biol. 318 (4): 1139–49. doi:10.1016/S0022-2836(02)00185-7. hdl:10261/109021. PMID 12054808.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nolasco S, Bellido J, Gonçalves J, et al. (2005). "Tubulin cofactor A gene silencing in mammalian cells induces changes in microtubule cytoskeleton, cell cycle arrest and cell death" (PDF). FEBS Lett. 579 (17): 3515–24. doi:10.1016/j.febslet.2005.05.022. hdl:10400.21/3045. PMID 15963512.
  • Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
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  • 1h7c: HUMAN TUBULIN CHAPERONE COFACTOR A
    1h7c: HUMAN TUBULIN CHAPERONE COFACTOR A


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