TAF7L

Protein-coding gene in the species Homo sapiens
TAF7L
Identifiers
AliasesTAF7L, CT40, TAF2Q, TATA-box binding protein associated factor 7 like
External IDsOMIM: 300314; MGI: 1921719; HomoloGene: 83311; GeneCards: TAF7L; OMA:TAF7L - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for TAF7L
Genomic location for TAF7L
BandXq22.1Start101,268,253 bp[1]
End101,293,057 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for TAF7L
Genomic location for TAF7L
BandX|X E3Start133,360,867 bp[2]
End133,377,239 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • gonad

  • testicle

  • stromal cell of endometrium

  • canal of the cervix

  • nucleus accumbens

  • skin of leg

  • right lobe of liver

  • seminal vesicula
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • embryo

  • decidua

  • embryo

  • Gonadal ridge

  • ovary

  • primary visual cortex

  • superior frontal gyrus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transcription coactivator activity
  • transcription factor binding
  • histone acetyltransferase binding
  • molecular function
Cellular component
  • cytoplasm
  • transcription factor TFIID complex
  • nucleus
Biological process
  • regulation of transcription by RNA polymerase II
  • multicellular organism development
  • cell differentiation
  • RNA polymerase II preinitiation complex assembly
  • transcription initiation from RNA polymerase II promoter
  • regulation of transcription, DNA-templated
  • spermatogenesis
  • transcription, DNA-templated
  • biological process
  • positive regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54457

74469

Ensembl

ENSG00000102387

ENSMUSG00000009596

UniProt

Q5H9L4

Q9D3R9

RefSeq (mRNA)

NM_001168474
NM_024885

NM_028958

RefSeq (protein)

NP_001161946
NP_079161

NP_083234

Location (UCSC)Chr X: 101.27 – 101.29 MbChr X: 133.36 – 133.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TATA-box binding protein associated factor 7 like is a protein that in humans is encoded by the TAF7L gene. [5]

Function

This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102387 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009596 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TATA-box binding protein associated factor 7 like". Retrieved 2018-03-03.

Further reading

  • Stouffs K, Willems A, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I (April 2006). "The role of the testis-specific gene hTAF7L in the aetiology of male infertility". Mol. Hum. Reprod. 12 (4): 263–7. doi:10.1093/molehr/gal020. PMID 16597641.
  • Akinloye O, Gromoll J, Callies C, Nieschlag E, Simoni M (October 2007). "Mutation analysis of the X-chromosome linked, testis-specific TAF7L gene in spermatogenic failure". Andrologia. 39 (5): 190–5. doi:10.1111/j.1439-0272.2007.00789.x. PMID 17714218. S2CID 13317343.
  • Yazarloo F, Shirkoohi R, Mobasheri MB, Emami A, Modarressi MH (March 2013). "Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern". Med. Oncol. 30 (1): 368. doi:10.1007/s12032-012-0368-8. PMID 23292864. S2CID 20377221.
  • Oh HR, An CH, Yoo NJ, Lee SH (July 2015). "Frameshift mutations of TAF7L gene, a core component for transcription by RNA polymerase II, in colorectal cancers". Pathol. Oncol. Res. 21 (3): 849–50. doi:10.1007/s12253-014-9832-4. PMID 25098277. S2CID 15595245.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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