Secretagogin

Protein-coding gene in the species Homo sapiens
SCGN
Identifiers
AliasesSCGN, CALBL, DJ501N12.8, SECRET, SEGN, setagin, secretagogin, EF-hand calcium binding protein
External IDsOMIM: 609202; MGI: 2384873; HomoloGene: 5088; GeneCards: SCGN; OMA:SCGN - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SCGN
Genomic location for SCGN
Band6p22.2Start25,652,201 bp[1]
End25,701,783 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for SCGN
Genomic location for SCGN
Band13|13 A3.1Start24,137,439 bp[2]
End24,175,197 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • beta cell

  • body of pancreas

  • testicle

  • rectum

  • pituitary gland

  • cerebellar cortex

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • anterior pituitary
Top expressed in
  • islet of Langerhans

  • neural layer of retina

  • olfactory epithelium

  • spermatid

  • lens

  • embryo

  • olfactory bulb

  • lumbar spinal ganglion

  • seminiferous tubule

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium ion binding
  • metal ion binding
Cellular component
  • cytoplasm
  • extracellular region
  • neuron projection
  • cytosol
  • transport vesicle membrane
  • synapse
  • membrane
  • cytoplasmic vesicle
  • nucleus
  • dendrite
  • presynapse
Biological process
  • regulation of cytosolic calcium ion concentration
  • biological process
  • regulation of presynaptic cytosolic calcium ion concentration
  • regulation of long-term synaptic potentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10590

214189

Ensembl

ENSG00000079689

ENSMUSG00000021337

UniProt

O76038

Q91WD9

RefSeq (mRNA)

NM_006998

NM_145399

RefSeq (protein)

NP_008929

NP_663374

Location (UCSC)Chr 6: 25.65 – 25.7 MbChr 13: 24.14 – 24.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Secretagogin is a protein that in humans is encoded by the SCGN gene.[5][6]

Function

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in potassium chloride-stimulated calcium flux and cell proliferation.[6] This protein plays an important role in the release of the stress hormone Corticotropin-releasing hormone (CRH) and which only then enables stress processes in the brain.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079689 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021337 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wagner L; Oliyarnyk O; Gartner W; Nowotny P; Groeger M; Kaserer K; Waldhausl W; Pasternack MS (Sep 2000). "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein". J Biol Chem. 275 (32): 24740–51. doi:10.1074/jbc.M001974200. PMID 10811645.
  6. ^ a b "Entrez Gene: SCGN secretagogin, EF-hand calcium binding protein".

Further reading

  • Gartner W, Lang W, Leutmetzer F, et al. (2002). "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein". Cereb. Cortex. 11 (12): 1161–9. doi:10.1093/cercor/11.12.1161. PMID 11709487.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Zhan X; Evans CO; Oyesiku NM; Desiderio DM (2004). "Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas". Pituitary. 6 (4): 189–202. doi:10.1023/B:PITU.0000023426.99808.40. PMID 15237930. S2CID 29004965.
  • Zierhut B, Daneva T, Gartner W, et al. (2005). "Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene". Biochem. Biophys. Res. Commun. 329 (4): 1193–9. doi:10.1016/j.bbrc.2005.02.093. PMID 15766553.
  • Skovhus KV, Bergholdt R, Erichsen C, et al. (2007). "Identification and characterization of secretagogin promoter activity". Scand. J. Immunol. 64 (6): 639–45. doi:10.1111/j.1365-3083.2006.01854.x. PMID 17083620. S2CID 13567265.
  • Romanov R.; Alpar A.; et al. (2014). "A secretagogin locus of the mammalian hypothalamus controls stress hormone release". EMBO Journal. 34 (1): 36–54. doi:10.15252/embj.201488977. PMC 4291479. PMID 25430741.
  • Téllez de Meneses, Pablo G.; Pérez-Revuelta, Laura; Canal-Alonso, Ángel; Hernández-Pérez, Carlos; Cocho, Teresa; Valero, Jorge; Weruaga, Eduardo; Díaz, David; Alonso, José R. (2023). "Immunohistochemical distribution of secretagogin in the mouse brain". Frontiers in Neuroanatomy. 17. doi:10.3389/fnana.2023.1224342. PMC 10498459. PMID 37711587.


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