SURF4

SURF4
Identifiers
Aliases	SURF4, ERV29, surfeit 4
External IDs	OMIM: 185660; MGI: 98445; HomoloGene: 6052; GeneCards: SURF4; OMA:SURF4 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.2 Start 133,361,450 bp[1] End 133,376,166 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans stromal cell of endometrium duodenum body of pancreas placenta right lobe of liver gallbladder smooth muscle tissue left adrenal gland left adrenal cortex n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment transport vesicle endoplasmic reticulum membrane Golgi membrane plasma membrane azurophil granule membrane cytosol Biological process early endosome to Golgi transport positive regulation of organelle organization protein exit from endoplasmic reticulum Golgi organization retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6836 20932 Ensembl ENSG00000148248 ENSG00000280951 n/a UniProt O15260 Q64310 RefSeq (mRNA) NM_001280788 NM_001280789 NM_001280790 NM_001280791 NM_001280792 NM_001280793 NM_033161 NM_011512 RefSeq (protein) NP_001267717 NP_001267718 NP_001267719 NP_001267720 NP_001267721 NP_001267722 NP_149351 NP_035642 Location (UCSC) Chr 9: 133.36 – 133.38 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies.^[4][5] Surf4 is involved in trafficking soluble (i.e. non-membrane-bound) proteins, namely lipoproteins and PCSK9.^[4] It recognizes cargo proteins via a three-amino-acid sequence near the N-termini.^[4] The related protein in yeast is called Erv29p.^[5]

This gene is named based on its location in the surfeit gene cluster, composed of six housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. Surf4's yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles.^[6]

Eliminating Surf4 in the liver reduces the amount of lipid in the plasma and prevents atherosclerosis in mice.^[4]